FIG 2

Myocardial invasion is continuous during pneumococcal bacteremia. (A) Bacterial titers in the blood of individual infected mice (diamonds) at the time of euthanasia. (B) Average number of discrete microlesions per heart section detected at each time point on H&E-stained slides viewed at a magnification ×20. The results are averages for 5 nonadjacent sections per heart. (C) Enumeration (natural log) of pneumococcal replication points within heart sections determined by IFM. Black horizontal bars, average value for the cohort. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.