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Bacterial Infections

Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis

Jennifer K. Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L. Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche, Sara M. Dann, Robert A. Britton, Anthony Haag, Tor C. Savidge
Vincent B. Young, Editor
Jennifer K. Spinler
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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  • ORCID record for Jennifer K. Spinler
Jennifer Auchtung
cAlkek Center for Metagenomics & Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, USA
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Aaron Brown
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Prapaporn Boonma
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Numan Oezguen
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Caná L. Ross
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Ruth Ann Luna
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Jessica Runge
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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James Versalovic
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Alex Peniche
dDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
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Sara M. Dann
dDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
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Robert A. Britton
cAlkek Center for Metagenomics & Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, USA
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Anthony Haag
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Tor C. Savidge
aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
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Vincent B. Young
University of Michigan—Ann Arbor
Roles: Editor
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DOI: 10.1128/IAI.00303-17
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Article Information

DOI 
https://doi.org/10.1128/IAI.00303-17
PubMed 
28760934

Published By 
American Society for Microbiology Journals
History 
  • Received April 28, 2017
  • Returned for modification June 6, 2017
  • Accepted July 24, 2017
  • Published online September 20, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .
Editors and / or Reviewers 
  • Vincent B. Young, Editor, University of Michigan—Ann Arbor

Article Versions

  • Accepted Manuscript version (July 31, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Jennifer K. Spinlera,b,
  2. Jennifer Auchtungc,
  3. Aaron Browna,b,
  4. Prapaporn Boonmaa,b,
  5. Numan Oezguena,b,
  6. Caná L. Rossa,b,
  7. Ruth Ann Lunaa,b,
  8. Jessica Rungea,b,
  9. James Versalovica,b,
  10. Alex Peniched,
  11. Sara M. Dannd,
  12. Robert A. Brittonc,
  13. Anthony Haaga,b and
  14. Tor C. Savidgea,b
  1. aDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA
  2. bTexas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA
  3. cAlkek Center for Metagenomics & Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, USA
  4. dDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
  • Address correspondence to Jennifer K. Spinler, spinler{at}bcm.edu.
  • Citation Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC. 2017. Next-generation probiotics targeting Clostridium difficile through precursor-directed antimicrobial biosynthesis. Infect Immun 85:e00303-17. https://doi.org/10.1128/IAI.00303-17 .

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Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis
Jennifer K. Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L. Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche, Sara M. Dann, Robert A. Britton, Anthony Haag, Tor C. Savidge
Infection and Immunity Sep 2017, 85 (10) e00303-17; DOI: 10.1128/IAI.00303-17

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Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis
Jennifer K. Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L. Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche, Sara M. Dann, Robert A. Britton, Anthony Haag, Tor C. Savidge
Infection and Immunity Sep 2017, 85 (10) e00303-17; DOI: 10.1128/IAI.00303-17
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KEYWORDS

Anti-Bacterial Agents
Clostridium Infections
Clostridium difficile
Glyceraldehyde
Glycerol
Lactobacillus reuteri
probiotics
Propane
Clostridium difficile
Lactobacillus reuteri
next-generation probiotics
reuterin
antimicrobial resistance

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