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Molecular Pathogenesis

The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli

Nitesh Sule, Sasi Pasupuleti, Nandita Kohli, Rani Menon, Lawrence J. Dangott, Michael D. Manson, Arul Jayaraman
Vincent B. Young, Editor
Nitesh Sule
aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
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Sasi Pasupuleti
aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
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Nandita Kohli
aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
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Rani Menon
aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
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Lawrence J. Dangott
bDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
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Michael D. Manson
cDepartment of Biology, Texas A&M University, College Station, Texas, USA
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Arul Jayaraman
aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
dDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, College Station, Texas, USA
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Vincent B. Young
University of Michigan—Ann Arbor
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DOI: 10.1128/IAI.00431-17
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Article Information

DOI 
https://doi.org/10.1128/IAI.00431-17
PubMed 
28717028

Published By 
American Society for Microbiology Journals
History 
  • Received June 13, 2017
  • Accepted July 7, 2017
  • Published online September 20, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .
Editors and / or Reviewers 
  • Vincent B. Young, Editor, University of Michigan—Ann Arbor

Article Versions

  • Accepted Manuscript version (July 17, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Nitesh Sulea,
  2. Sasi Pasupuletia,
  3. Nandita Kohlia,
  4. Rani Menona,
  5. Lawrence J. Dangottb,
  6. Michael D. Mansonc and
  7. Arul Jayaramana,d
  1. aArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA
  2. bDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
  3. cDepartment of Biology, Texas A&M University, College Station, Texas, USA
  4. dDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, College Station, Texas, USA
  • Address correspondence to Michael D. Manson, mike{at}mail.bio.tamu.edu, or Arul Jayaraman, arulj{at}tamu.edu.
  • Citation Sule N, Pasupuleti S, Kohli N, Menon R, Dangott LJ, Manson MD, Jayaraman A. 2017. The norepinephrine metabolite 3,4-dihydroxymandelic acid is produced by the commensal microbiota and promotes chemotaxis and virulence gene expression in enterohemorrhagic Escherichia coli. Infect Immun 85:e00431-17. https://doi.org/10.1128/IAI.00431-17 .

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The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli
Nitesh Sule, Sasi Pasupuleti, Nandita Kohli, Rani Menon, Lawrence J. Dangott, Michael D. Manson, Arul Jayaraman
Infection and Immunity Sep 2017, 85 (10) e00431-17; DOI: 10.1128/IAI.00431-17

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The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli
Nitesh Sule, Sasi Pasupuleti, Nandita Kohli, Rani Menon, Lawrence J. Dangott, Michael D. Manson, Arul Jayaraman
Infection and Immunity Sep 2017, 85 (10) e00431-17; DOI: 10.1128/IAI.00431-17
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KEYWORDS

chemotaxis
enterohemorrhagic Escherichia coli
Mandelic Acids
microbiota
Symbiosis
virulence factors
DHMA
EHEC
norepinephrine
chemotaxis
interkingdom signaling
virulence

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