Letter to the Editor | Spotlight

Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis

John A. Lees, Matthijs Brouwer, Arie van der Ende, Julian Parkhill, Diederik van de Beek, Stephen D. Bentley
Liise-anne Pirofski, Editor
DOI: 10.1128/IAI.01061-16

Article Information

DOI 
https://doi.org/10.1128/IAI.01061-16
PubMed 
28232521
Published By 
American Society for Microbiology Journals
History 
  • Published online February 23, 2017.
Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .
Editors and / or Reviewers 
  • Liise-anne Pirofski, Editor, Albert Einstein College of Medicine

Author Information

  1. John A. Leesa,
  2. Matthijs Brouwerb,
  3. Arie van der Endec,d,
  4. Julian Parkhilla,
  5. Diederik van de Beekb and
  6. Stephen D. Bentleya
  1. aWellcome Trust Sanger Institute, Hinxton, United Kingdom
  2. bDepartment of Neurology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands
  3. cDepartment of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands
  4. dNetherlands Reference Laboratory for Bacterial Meningitis, Academic Medical Center, Amsterdam, The Netherlands
  • Address correspondence to Stephen D. Bentley, sdb{at}sanger.ac.uk.

  • Citation Lees JA, Brouwer M, van der Ende A, Parkhill J, van de Beek D, Bentley SD. 2017. Within-host sampling of a natural population shows signs of selection on Pde1 during bacterial meningitis. Infect Immun 85:e01061-16. https://doi.org/10.1128/IAI.01061-16 .

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KEYWORDS

DHH family protein
bacterial meningitis
pde1
pneumococcal pathogenesis
selection
Cyclic Nucleotide Phosphodiesterases, Type 1
Meningitis, Pneumococcal
Streptococcus pneumoniae

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