Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Infection and Immunity
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Host Response and Inflammation

Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment

Kadar Moideen, Nathella Pavan Kumar, Dina Nair, Vaithilingam V. Banurekha, Ramalingam Bethunaickan, Subash Babu
Sabine Ehrt, Editor
Kadar Moideen
aNational Institute of Health-NIRT-International Center for Excellence in Research, Chennai, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nathella Pavan Kumar
aNational Institute of Health-NIRT-International Center for Excellence in Research, Chennai, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dina Nair
bDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vaithilingam V. Banurekha
bDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ramalingam Bethunaickan
cDepartment of Immunology, National Institute for Research in Tuberculosis, Chennai, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Subash Babu
aNational Institute of Health-NIRT-International Center for Excellence in Research, Chennai, India
dLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sabine Ehrt
Weill Cornell Medical College
Roles: Editor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/IAI.00008-18
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG 1
    • Open in new tab
    • Download powerpoint
    FIG 1

    PTB is associated with elevated platelet and neutrophil counts. The absolute counts of white blood cells (WBCs), red blood cells (RBCs), platelets, lymphocytes, neutrophils, and eosinophils in PTB and LTB individuals were determined by use of a hematology analyzer. Data are shown as scatter plots, with the bars representing the geometric means. P values were calculated using the Mann-Whitney U test.

  • FIG 2
    • Open in new tab
    • Download powerpoint
    FIG 2

    PTB is associated with enhanced levels of neutrophil granular proteins and reversal following ATT. (A) The plasma levels of myeloperoxidase (MPO), neutrophil elastase, and proteinase 3 from PTB (n = 44) and LTB (n = 44) individuals were measured by ELISA. Data are shown as scatter plots, with the bars representing the geometric means. P values were calculated using the Mann-Whitney U test. (B) The plasma levels of MPO, elastase, and proteinase 3 from PTB individuals at the baseline (pretreatment [pre-T]) and following 6 months of ATT (posttreatment [post-T]) were measured by ELISA. P values were calculated using the Wilcoxon matched-pair test. (C) Absolute neutrophil counts (ANC) were correlated with the plasma levels of MPO, elastase, and proteinase 3 in all individuals. P and r values were calculated using the Spearman rank correlation test at the 95% confidence intervals. (D) ROC analysis to estimate the sensitivity, specificity, and area under the curve was performed using neutrophil granular proteins to estimate the capacity of these factors to distinguish PTB individuals from LTB individuals.

  • FIG 3
    • Open in new tab
    • Download powerpoint
    FIG 3

    PTB is associated with enhanced levels of eosinophil granular proteins and reversal following ATT. (A) The plasma levels of major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPX) from PTB and LTB individuals were measured by ELISA. Data are shown as scatter plots, with the bars representing the geometric means. P values were calculated using the Mann-Whitney U test. (B) The plasma levels of MBP, EDN, ECP, and EPX from PTB individuals at the baseline (pretreatment [pre-T]) and following 6 months of ATT (posttreatment [post-T]) were measured by ELISA. P values were calculated using the Wilcoxon matched-pair test. (C) Absolute eosinophil counts (AEC) was correlated with the plasma levels of MBP, EDN, ECP, and EPX in all individuals. P and r values were calculated using the Spearman rank correlation test at the 95% confidence interval. (D) ROC analysis to estimate the sensitivity, specificity, and area under the curve was performed using eosinophil granular proteins to estimate the capacity of these factors to distinguish PTB individuals from LTB individuals.

Tables

  • Figures
  • TABLE 1

    Demographics of the study population

    CharacteristicValue(s) for the following group:
    PTBLTB
    No. of subjects4444
    No. of males/no. of females29/1527/17
    Median (range) age (yr)41 (24–67)44 (25–65)
    Median (range) ht (cm)159 (133–173)164 (140–184)
    Median (range) wt (kg)45 (30–81)49 (32–90)
PreviousNext
Back to top
Download PDF
Citation Tools
Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment
Kadar Moideen, Nathella Pavan Kumar, Dina Nair, Vaithilingam V. Banurekha, Ramalingam Bethunaickan, Subash Babu
Infection and Immunity May 2018, 86 (6) e00008-18; DOI: 10.1128/IAI.00008-18

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Infection and Immunity article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment
(Your Name) has forwarded a page to you from Infection and Immunity
(Your Name) thought you would be interested in this article in Infection and Immunity.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment
Kadar Moideen, Nathella Pavan Kumar, Dina Nair, Vaithilingam V. Banurekha, Ramalingam Bethunaickan, Subash Babu
Infection and Immunity May 2018, 86 (6) e00008-18; DOI: 10.1128/IAI.00008-18
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

neutrophils
tuberculosis
eosinophils
granular proteins

Related Articles

Cited By...

About

  • About IAI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #IAIjournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0019-9567; Online ISSN: 1098-5522