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Bacterial Infections

Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections

Sofiya N. Micheva-Viteva, Brittany N. Ross, Jun Gao, Samantha Adikari, Pengfei Zhang, Judith R. Mourant, Terry H. Wu, James H. Werner, Alfredo G. Torres, Elizabeth Hong-Geller
Manuela Raffatellu, Editor
Sofiya N. Micheva-Viteva
aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Brittany N. Ross
bDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
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Jun Gao
aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Samantha Adikari
aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Pengfei Zhang
cCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Judith R. Mourant
aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Terry H. Wu
dUniversity of New Mexico Health Sciences Center, Department of Internal Medicine, Albuquerque, New Mexico, USA
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James H. Werner
cCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Alfredo G. Torres
bDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
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Elizabeth Hong-Geller
aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
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Manuela Raffatellu
University of California San Diego School of Medicine
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DOI: 10.1128/IAI.00592-18
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Article Information

DOI 
https://doi.org/10.1128/IAI.00592-18
PubMed 
30323029

Published By 
American Society for Microbiology Journals
History 
  • Received July 27, 2018
  • Returned for modification August 7, 2018
  • Accepted October 9, 2018
  • Published online December 19, 2018.

Copyright & Usage 
Copyright © 2018 Micheva-Viteva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Manuela Raffatellu, Editor, University of California San Diego School of Medicine

Article Versions

  • Accepted Manuscript version (October 15, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Sofiya N. Micheva-Vitevaa,
  2. Brittany N. Rossb,
  3. Jun Gaoa,
  4. Samantha Adikaria,
  5. Pengfei Zhangc,
  6. Judith R. Mouranta,
  7. Terry H. Wud,
  8. James H. Wernerc,
  9. Alfredo G. Torresb and
  10. Elizabeth Hong-Gellera
  1. aBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
  2. bDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
  3. cCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA
  4. dUniversity of New Mexico Health Sciences Center, Department of Internal Medicine, Albuquerque, New Mexico, USA
  • Address correspondence to Elizabeth Hong-Geller, ehong{at}lanl.gov.
  • Citation Micheva-Viteva SN, Ross BN, Gao J, Adikari S, Zhang P, Mourant JR, Wu TH, Werner JH, Torres AG, Hong-Geller E. 2019. Increased mortality in mice following immunoprophylaxis therapy with high dosage of nicotinamide in Burkholderia persistent infections. Infect Immun 87:e00592-18. https://doi.org/10.1128/IAI.00592-18.

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Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections
Sofiya N. Micheva-Viteva, Brittany N. Ross, Jun Gao, Samantha Adikari, Pengfei Zhang, Judith R. Mourant, Terry H. Wu, James H. Werner, Alfredo G. Torres, Elizabeth Hong-Geller
Infection and Immunity Dec 2018, 87 (1) e00592-18; DOI: 10.1128/IAI.00592-18

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Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections
Sofiya N. Micheva-Viteva, Brittany N. Ross, Jun Gao, Samantha Adikari, Pengfei Zhang, Judith R. Mourant, Terry H. Wu, James H. Werner, Alfredo G. Torres, Elizabeth Hong-Geller
Infection and Immunity Dec 2018, 87 (1) e00592-18; DOI: 10.1128/IAI.00592-18
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KEYWORDS

Burkholderia
antimicrobial resistance
bacterial persistence
microfluidics
nicotinamide
relA

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