Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Infection and Immunity
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

Table of Contents

January 2020; Volume 88,Issue 1

Spotlight

  • Free
    Articles of Significant Interest in This Issue
    Spotlight
    Articles of Significant Interest in This Issue

Minireviews

  • Type 3 Immunity during <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Infection: Too Much of a Good Thing?
    Minireview
    Type 3 Immunity during Clostridioides difficile Infection: Too Much of a Good Thing?

    Clostridioides (formerly known as Clostridium) difficile is the leading cause of hospital-acquired gastrointestinal infections in the United States and one of three urgent health care threats identified by the Centers for Disease Control and Prevention. C. difficile disease is mediated by the production of toxins that disrupt the epithelial...

    Mahmoud M. Saleh, William A. Petri
  • Biomarkers for Detecting Resilience against Mycobacterial Disease in Animals
    Minireview
    Biomarkers for Detecting Resilience against Mycobacterial Disease in Animals

    Paratuberculosis and bovine tuberculosis are two mycobacterial diseases of ruminants which have a considerable impact on livestock health, welfare, and production. These are chronic “iceberg” diseases which take years to manifest and in which many subclinical cases remain undetected. Suggested biomarkers to detect infected or diseased animals are numerous and include cytokines, peptides, and expression of specific genes; however, these...

    Kathryn Wright, Karren Plain, Auriol Purdie, Bernadette M. Saunders, Kumudika de Silva

Molecular Pathogenesis

  • Prominent Binding of Human and Equine Fibrinogen to <span class="named-content genus-species" id="named-content-1">Streptococcus equi</span> subsp. <em>zooepidemicus</em> Is Mediated by Specific SzM Types and Is a Distinct Phenotype of Zoonotic Isolates
    Molecular Pathogenesis
    Prominent Binding of Human and Equine Fibrinogen to Streptococcus equi subsp. zooepidemicus Is Mediated by Specific SzM Types and Is a Distinct Phenotype of Zoonotic Isolates

    Streptococcus equi subsp. zooepidemicus is an important pathogen in horses that causes severe diseases such as pneumonia and abortion. Furthermore, it is a zoonotic agent, and contact with horses is a known risk factor. In this study, we investigated the working hypothesis that the zoonotic potential varies among...

    René Bergmann, Maria-Christin Jentsch, Albrecht Uhlig, Uwe Müller, Mark van der Linden, Magnus Rasmussen, Andrew Waller, Maren von Köckritz-Blickwede, Christoph Georg Baums

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

  • No Evidence of Apoptotic Response of the Potato Psyllid <em>Bactericera cockerelli</em> to “<em>Candidatus</em> Liberibacter solanacearum” at the Gut Interface
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    No Evidence of Apoptotic Response of the Potato Psyllid Bactericera cockerelli to “Candidatus Liberibacter solanacearum” at the Gut Interface

    “Candidatus Liberibacter solanacearum” is a pathogen transmitted by the potato psyllid Bactericera cockerelli (Šulc) (Hemiptera: Triozidae) in a persistent manner. In this study, we investigated the molecular interaction between “Ca. Liberibacter solanacearum” and the potato psyllid at the gut interface. Specifically, we focused on the apoptotic response of potato psyllids to the infection by two “Ca....

    Xiao-Tian Tang, Cecilia Tamborindeguy
  • Mutation of the Transcriptional Regulator YtoI Rescues <span class="named-content genus-species" id="named-content-1">Listeria monocytogenes</span> Mutants Deficient in the Essential Shared Metabolite 1,4-Dihydroxy-2-Naphthoate (DHNA)
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Mutation of the Transcriptional Regulator YtoI Rescues Listeria monocytogenes Mutants Deficient in the Essential Shared Metabolite 1,4-Dihydroxy-2-Naphthoate (DHNA)

    Listeria monocytogenes, a Gram-positive, facultative intracellular pathogen, survives and replicates in the cytosol of host cells. Synthesis of 1,4-dihydroxy-2-naphthoate (DHNA), an intermediate of menaquinone biosynthesis, is essential for cytosolic survival of L. monocytogenes independent from its...

    Grischa Y. Chen, Cheng-Yen Kao, Hans B. Smith, Drew P. Rust, Zachary M. Powers, Alexandria Y. Li, John-Demian Sauer
  • Human Enteric Defensin 5 Promotes <em>Shigella</em> Infection of Macrophages
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages

    Human α-defensins are 3- to 5-kDa disulfide-bridged peptides with a multitude of antimicrobial activities and immunomodulatory functions. Recent studies show that human enteric α-defensin 5 (HD5), a host defense peptide important for intestinal homeostasis and innate immunity, aids the highly infectious enteropathogen Shigella in breaching the intestinal epithelium in vitro and in vivo.

    Dan Xu, Chongbing Liao, Jiu Xiao, Kun Fang, Wei Zhang, Weirong Yuan, Wuyuan Lu

Bacterial Infections

  • A Rare Opportunist, <em>Morganella morganii</em>, Decreases Severity of Polymicrobial Catheter-Associated Urinary Tract Infection
    Bacterial Infections | Spotlight
    A Rare Opportunist, Morganella morganii, Decreases Severity of Polymicrobial Catheter-Associated Urinary Tract Infection

    Catheter-associated urinary tract infections (CAUTIs) are common hospital-acquired infections and frequently polymicrobial, which complicates effective treatment. However, few studies experimentally address the consequences of polymicrobial interactions within the urinary tract, and the clinical significance of polymicrobial bacteriuria is not fully understood.

    Brian S. Learman, Aimee L. Brauer, Kathryn A. Eaton, Chelsie E. Armbruster
  • Open Access
    <em>Mycobacterium tuberculosis</em> LipE Has a Lipase/Esterase Activity and Is Important for Intracellular Growth and <em>In Vivo</em> Infection
    Bacterial Infections
    Mycobacterium tuberculosis LipE Has a Lipase/Esterase Activity and Is Important for Intracellular Growth and In Vivo Infection

    Mycobacterium tuberculosis Rv3775 (LipE) was annotated as a putative lipase. However, its lipase activity has never been characterized, and its precise role in tuberculosis (TB) pathogenesis has not been thoroughly studied to date. We overexpressed and purified the recombinant LipE (rLipE) protein and demonstrated that LipE has a lipase/esterase activity. rLipE...

    Dong Yang, Shaoji Li, Jennifer Stabenow, Lillian Zalduondo, Ying Kong
  • <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation
    Bacterial Infections
    Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation

    Antibiotic-resistant Klebsiella pneumoniae isolates constitute a great clinical challenge. One important resistance mechanism in K. pneumoniae is the metallo-β-lactamases (MBLs), which require zinc for their function. Thus, zinc chelation could be a strategy to resensitize...

    Harpa Karadottir, Maarten Coorens, Zhihai Liu, Yang Wang, Birgitta Agerberth, Christian G. Giske, Peter Bergman
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia
    Bacterial Infections | Spotlight
    Salmonella enterica Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia

    Salmonella enterica serovar Typhimurium (S. Typhimurium) relies upon the inner membrane protein PbgA to enhance outer membrane (OM) integrity and promote virulence in mice. The PbgA transmembrane domain (residues 1 to 190) is essential for viability, while the periplasmic domain (residues 191 to 586) is dispensable. Residues within the basic region (residues...

    Melina B. Cian, Nicole P. Giordano, Revathi Masilamani, Keaton E. Minor, Zachary D. Dalebroux
  • <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice
    Bacterial Infections | Spotlight
    Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice

    To survive and replicate during infection, pathogens utilize different carbon and energy sources depending on the nutritional landscape of their host microenvironment. Salmonella enterica serovar Typhimurium is an intracellular bacterial pathogen that occupies diverse cellular niches. While it is clear that Salmonella Typhimurium requires access to glucose...

    Abigail L. Reens, Toni A. Nagy, Corrella S. Detweiler

Host Response and Inflammation

  • <em>Chlamydia psittaci</em>-Infected Dendritic Cells Communicate with NK Cells via Exosomes To Activate Antibacterial Immunity
    Host Response and Inflammation
    Chlamydia psittaci-Infected Dendritic Cells Communicate with NK Cells via Exosomes To Activate Antibacterial Immunity

    Dendritic cells (DCs) and natural killer (NK) cells are critically involved in the early response against various bacterial microbes. Functional activation of infected DCs and NK cell-mediated gamma interferon (IFN-γ) secretion essentially contribute to the protective immunity against Chlamydia. How DCs and NK cells cooperate during the antichlamydial response is not fully understood.

    Nadine Radomski, Axel Karger, Kati Franzke, Elisabeth Liebler-Tenorio, Rico Jahnke, Svea Matthiesen, Michael R. Knittler
  • Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated <span class="named-content genus-species" id="named-content-1">Mycoplasma gallisepticum</span> and Low-Pathogenic Avian Influenza A Virus in Chickens
    Host Response and Inflammation
    Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated Mycoplasma gallisepticum and Low-Pathogenic Avian Influenza A Virus in Chickens

    The avian pathogen Mycoplasma gallisepticum, the etiological agent of chronic respiratory disease in chickens, exhibits enhanced pathogenesis in the presence of a copathogen such as low-pathogenic avian influenza virus (LPAIV).

    J. A. Canter, E. R. Tulman, J. Beaudet, D.-H. Lee, M. May, S. M. Szczepanek, S. J. Geary
  • Divergent Antigen-Specific Cellular Immune Responses during Asymptomatic Subclinical and Clinical States of Disease in Cows Naturally Infected with <span class="named-content genus-species" id="named-content-1">Mycobacterium avium</span> subsp. <em>paratuberculosis</em>
    Host Response and Inflammation
    Divergent Antigen-Specific Cellular Immune Responses during Asymptomatic Subclinical and Clinical States of Disease in Cows Naturally Infected with Mycobacterium avium subsp. paratuberculosis

    Infection of the host with Mycobacterium avium subsp. paratuberculosis results in chronic and progressive enteritis that traverses both subclinical and clinical stages. The mechanism(s) for the shift from an asymptomatic subclinical disease state to advanced clinical disease is not fully understood.

    J. R. Stabel, J. P. Bannantine
  • A Loss-of-Function Mutation in the Integrin Alpha L (<em>Itgal</em>) Gene Contributes to Susceptibility to <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Serovar Typhimurium Infection in Collaborative Cross Strain CC042
    Host Response and Inflammation | Spotlight
    A Loss-of-Function Mutation in the Integrin Alpha L (Itgal) Gene Contributes to Susceptibility to Salmonella enterica Serovar Typhimurium Infection in Collaborative Cross Strain CC042

    Salmonella is an intracellular bacterium found in the gastrointestinal tract of mammalian, avian, and reptilian hosts. Mouse models have been extensively used to model in vivo distinct aspects of human Salmonella infections and have led to the identification of several host susceptibility genes. We have investigated the susceptibility of Collaborative Cross strains to intravenous infection with...

    Jing Zhang, Megan Teh, Jamie Kim, Megan M. Eva, Romain Cayrol, Rachel Meade, Anastasia Nijnik, Xavier Montagutelli, Danielle Malo, Jean Jaubert
  • Open Access
    Early Growth Response 1 Deficiency Protects the Host against <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Lung Infection
    Host Response and Inflammation
    Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection

    Pseudomonas aeruginosa is an opportunistic pathogen that is a common cause of nosocomial infections. The molecular mechanisms governing immune responses to P. aeruginosa infection remain incompletely defined. Early growth response 1 (Egr-1) is a zinc-finger transcription factor that controls...

    Zheng Pang, Renee Raudonis, Craig McCormick, Zhenyu Cheng
  • The Nature of Antibacterial Adaptive Immune Responses against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Is Dependent on the Growth Phase and Extracellular Peptidoglycan
    Host Response and Inflammation
    The Nature of Antibacterial Adaptive Immune Responses against Staphylococcus aureus Is Dependent on the Growth Phase and Extracellular Peptidoglycan

    Staphylococcus aureus has evolved different strategies to evade the immune response, which play an important role in its pathogenesis. The bacteria express and shed various cell wall components and toxins during different stages of growth that may affect the protective T cell responses to extracellular and intracellular...

    Payal P. Balraadjsing, Lisbeth D. Lund, Yuri Souwer, Sebastian A. J. Zaat, Hanne Frøkiær, Esther C. de Jong

Microbial Immunity and Vaccines

  • Construction and Characterization of the <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> <em>sigE fadD26</em> Unmarked Double Mutant as a Vaccine Candidate
    Microbial Immunity and Vaccines
    Construction and Characterization of the Mycobacterium tuberculosis sigE fadD26 Unmarked Double Mutant as a Vaccine Candidate

    Despite the great increase in the understanding of the biology and pathogenesis of Mycobacterium tuberculosis achieved by the scientific community in recent decades, tuberculosis (TB) still represents one of the major threats to global human health.

    Rogelio Hernandez-Pando, Sung Jae Shin, Simon Clark, Stefano Casonato, Martin Becerril-Zambrano, Hongmin Kim, Francesca Boldrin, Dulce Mata-Espinoza, Roberta Provvedi, Ainhoa Arbues, Brenda Marquina-Castillo, Laura Cioetto Mazzabò, Jorge Barrios-Payan, Carlos Martin, Sang-Nae Cho, Ann Williams, Riccardo Manganelli
  • Clearance of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> from <em>In Vivo</em> Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens
    Microbial Immunity and Vaccines | Spotlight
    Clearance of Staphylococcus aureus from In Vivo Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens

    Staphylococcus aureus is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-...

    Janette M. Harro, Yvonne Achermann, Jeffrey A. Freiberg, Devon L. Allison, Kristen J. Brao, Dimitrius P. Marinos, Salar Sanjari, Jeff G. Leid, Mark E. Shirtliff
  • Open Access
    Toll-Like Receptor 2 (TLR2) and TLR4 Mediate the IgA Immune Response Induced by <span class="named-content genus-species" id="named-content-1">Mycoplasma hyopneumoniae</span>
    Microbial Immunity and Vaccines
    Toll-Like Receptor 2 (TLR2) and TLR4 Mediate the IgA Immune Response Induced by Mycoplasma hyopneumoniae

    IgA plays an important role in mucosal immunity against infectious pathogens; however, the molecular mechanism of IgA secretion in response to infection remains largely unknown, particularly in Mycoplasma spp. In this study, we found that the levels of IgA in the peripheral blood serum, bronchoalveolar lavage fluid, nasal mucosa, trachea, hilar lymph nodes, and lung...

    Xia Li, Yun-ke Zhang, Bao Yin, Jing-bo Liang, Fei Jiang, Wen-xue Wu

Host-Associated Microbial Communities

  • Open Access
    Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis
    Host-Associated Microbial Communities
    Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis

    Food allergy is a life-threatening response to specific foods, and microbiota imbalance (dysbiosis) in gut is considered a cause of this disease. Meanwhile, the host immune response also plays an important role in the disease. Notably, interleukin 33 (IL-33) released from damaged or necrotic intestinal epithelial cells facilitates IL-2-producing CD4 helper T (Th2) responses. However, causal relationships between the gut and oral...

    Shohei Matsui, Hideo Kataoka, Jun-Ichi Tanaka, Mariko Kikuchi, Haruka Fukamachi, Hirobumi Morisaki, Hitomi Matsushima, Kenji Mishima, Shoji Hironaka, Takashi Takaki, Nobuo Okahashi, Yasubumi Maruoka, Hirotaka Kuwata

Masthead

  • Free
    Editorial Board
    Masthead
    Editorial Board
PreviousNext
Back to top

Infection and Immunity: 88 (1)

In This Issue

volume 88, issue 1
  • Table of Contents (PDF)
  • Journal Cover & Description

Issue Spotlights

  • Articles of Significant Interest in This Issue
Sign up for alerts

Jump to

  • Spotlight
  • Minireviews
  • Molecular Pathogenesis
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
  • Bacterial Infections
  • Host Response and Inflammation
  • Microbial Immunity and Vaccines
  • Host-Associated Microbial Communities
  • Masthead
  • Most Read
  • Most Cited
Loading
  • Pathogenic Mannheimia haemolytica Invades Differentiated Bovine Airway Epithelial Cells
  • Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies
  • An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector
  • Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence
More...

About

  • About IAI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #IAIjournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0019-9567; Online ISSN: 1098-5522