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Host Response and Inflammation

Endocervical miRNA Expression Profiles in Women Positive for Chlamydia trachomatis with Clinical Signs and/or Symptoms Are Distinct from Those in Women Positive for Chlamydia trachomatis without Signs and Symptoms

Teresa A. Batteiger, Nicole Spencer, Charity L. Washam, Stephanie Byrum, Michael Eledge, Byron E. Batteiger, Roger G. Rank, Laxmi Yeruva
Craig R. Roy, Editor
Teresa A. Batteiger
aDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
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Nicole Spencer
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
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Charity L. Washam
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
cDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Stephanie Byrum
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
cDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Michael Eledge
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
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Byron E. Batteiger
aDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
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Roger G. Rank
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
dDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Laxmi Yeruva
bArkansas Children’s Hospital Research Institute, Little Rock, Arkansas, USA
cDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
dDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
eArkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
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Craig R. Roy
Yale University School of Medicine
Roles: Editor
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DOI: 10.1128/IAI.00057-20
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ABSTRACT

Chlamydia trachomatis is the leading cause of sexually transmitted infections that may progress to pelvic inflammatory disease and infertility. No effective vaccine exists for Chlamydia, nor are there biomarkers available that readily predict disease progression. In this cross-sectional pilot study, we recruited symptomatic and asymptomatic women with C. trachomatis (CT) infection and asymptomatic, uninfected control women from an urban sexually transmitted disease clinic to determine if there were differences in microRNA (miRNA) expression. Infected women with signs and/or symptoms (CTSS) have distinct miRNA profiles compared to asymptomatic infected women (CTNS). In the CTSS group, miR-142 and -147 showed 2.2- to 6.9-fold increases in expression. In the CTNS group, miR-449c, -6779, -519d, -449a, and -2467 showed 3.9- to 9.0-fold increases in expression. In the CTNS group, cyclins and cell cycle regulation and IL-17 pathways were likely downregulated, while the same signaling pathways were upregulated in the CTSS group. In addition, in the CTSS group, additional inflammatory pathways associated with TNFR1 and IL-8 appear to be upregulated. The miRNA expression patterns differ between CT-infected symptomatic and asymptomatic women, and these differences may warrant further study.

FOOTNOTES

    • Received 5 March 2020.
    • Returned for modification 21 April 2020.
    • Accepted 10 July 2020.
    • Accepted manuscript posted online 20 July 2020.
  • Supplemental material is available online only.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

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Endocervical miRNA Expression Profiles in Women Positive for Chlamydia trachomatis with Clinical Signs and/or Symptoms Are Distinct from Those in Women Positive for Chlamydia trachomatis without Signs and Symptoms
Teresa A. Batteiger, Nicole Spencer, Charity L. Washam, Stephanie Byrum, Michael Eledge, Byron E. Batteiger, Roger G. Rank, Laxmi Yeruva
Infection and Immunity Sep 2020, 88 (10) e00057-20; DOI: 10.1128/IAI.00057-20

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Endocervical miRNA Expression Profiles in Women Positive for Chlamydia trachomatis with Clinical Signs and/or Symptoms Are Distinct from Those in Women Positive for Chlamydia trachomatis without Signs and Symptoms
Teresa A. Batteiger, Nicole Spencer, Charity L. Washam, Stephanie Byrum, Michael Eledge, Byron E. Batteiger, Roger G. Rank, Laxmi Yeruva
Infection and Immunity Sep 2020, 88 (10) e00057-20; DOI: 10.1128/IAI.00057-20
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KEYWORDS

Chlamydia
miRNA
signs and symptoms
endocervix
inflammation

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