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Molecular Pathogenesis

Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
Victor J. Torres, Editor
Xuyao Jiao
aDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA
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Sarah Smith
bKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom
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Gabrielle Stack
aDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA
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Qi Liang
bKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom
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Allan Bradley
bKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom
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Paul Kellam
bKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom
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Jorge E. Galán
aDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA
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Victor J. Torres
New York University School of Medicine
Roles: Editor
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DOI: 10.1128/IAI.00292-20
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Article Information

DOI 
https://doi.org/10.1128/IAI.00292-20
PubMed 
32661121

Published By 
American Society for Microbiology Journals
History 
  • Received May 14, 2020
  • Returned for modification June 19, 2020
  • Accepted July 6, 2020
  • Published online September 18, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Victor J. Torres, Editor, New York University School of Medicine

Article Versions

  • Accepted Manuscript version (July 13, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Xuyao Jiaoa*,
  2. Sarah Smithb,
  3. Gabrielle Stacka,
  4. Qi Liangb,
  5. Allan Bradleyb,
  6. Paul Kellamb and
  7. Jorge E. Galána
  1. aDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA
  2. bKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom
  • Address correspondence to Jorge E. Galán, jorge.galan{at}yale.edu.
  • ↵* Present address: Xuyao Jiao, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

  • Citation Jiao X, Smith S, Stack G, Liang Q, Bradley A, Kellam P, Galán JE. 2020. Generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies. Infect Immun 88:e00292-20. https://doi.org/10.1128/IAI.00292-20.

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Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
Infection and Immunity Sep 2020, 88 (10) e00292-20; DOI: 10.1128/IAI.00292-20

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Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
Infection and Immunity Sep 2020, 88 (10) e00292-20; DOI: 10.1128/IAI.00292-20
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    • ABSTRACT
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KEYWORDS

typhoid fever
bacterial pathogenesis
Salmonella typhi
Salmonella Paratyphi
infectious diseases
bacterial toxins
monoclonal antibodies
therapeutics

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