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Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Coxiella burnetii-Infected NK Cells Release Infectious Bacteria by Degranulation

Svea Matthiesen, Luca Zaeck, Kati Franzke, Rico Jahnke, Charlie Fricke, Michael Mauermeir, Stefan Finke, Anja Lührmann, Michael R. Knittler
Craig R. Roy, Editor
Svea Matthiesen
aInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Luca Zaeck
bInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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  • ORCID record for Luca Zaeck
Kati Franzke
cInstitute of Infectology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Rico Jahnke
aInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Charlie Fricke
aInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Michael Mauermeir
dMicrobiological Institute—Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
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Stefan Finke
bInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Anja Lührmann
dMicrobiological Institute—Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
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Michael R. Knittler
aInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald, Germany
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Craig R. Roy
Yale University School of Medicine
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DOI: 10.1128/IAI.00172-20
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ABSTRACT

Natural killer (NK) cells are critically involved in the early immune response against various intracellular pathogens, including Coxiella burnetii and Chlamydia psittaci. Chlamydia-infected NK cells functionally mature, induce cellular immunity, and protect themselves by killing the bacteria in secreted granules. Here, we report that infected NK cells do not allow intracellular multiday growth of Coxiella, as is usually observed in other host cell types. C. burnetii-infected NK cells display maturation and gamma interferon (IFN-γ) secretion, as well as the release of Coxiella-containing lytic granules. Thus, NK cells possess a potent program to restrain and expel different types of invading bacteria via degranulation. Strikingly, though, in contrast to Chlamydia, expulsed Coxiella organisms largely retain their infectivity and, hence, escape the cell-autonomous self-defense mechanism in NK cells.

FOOTNOTES

    • Received 22 March 2020.
    • Returned for modification 8 May 2020.
    • Accepted 10 August 2020.
    • Accepted manuscript posted online 17 August 2020.
  • Supplemental material is available online only.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

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Coxiella burnetii-Infected NK Cells Release Infectious Bacteria by Degranulation
Svea Matthiesen, Luca Zaeck, Kati Franzke, Rico Jahnke, Charlie Fricke, Michael Mauermeir, Stefan Finke, Anja Lührmann, Michael R. Knittler
Infection and Immunity Oct 2020, 88 (11) e00172-20; DOI: 10.1128/IAI.00172-20

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Coxiella burnetii-Infected NK Cells Release Infectious Bacteria by Degranulation
Svea Matthiesen, Luca Zaeck, Kati Franzke, Rico Jahnke, Charlie Fricke, Michael Mauermeir, Stefan Finke, Anja Lührmann, Michael R. Knittler
Infection and Immunity Oct 2020, 88 (11) e00172-20; DOI: 10.1128/IAI.00172-20
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KEYWORDS

cell-autonomous immunity
Chlamydia psittaci
Coxiella burnetii
NK cells

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