Cover photograph: The endothelial glycocalyx covers the luminal surface of blood vessels (white). In the buccal mucosa in pediatric Plasmodium falciparum malaria, we performed noninvasive imaging to allow for monitoring of the movement of red blood cells. Under normal conditions, the glycocalyx is impenetrable for red blood cells, but upon disease, the glycocalyx is shed, making room for cells in circulation. The so-called perfused boundary region increased in patients with malaria, and shed glycocalyx components were detected at increased amounts in plasma. Moreover, the noninvasive imaging allowed for the detection of sequestering parasites in vivo (purple) as well as perivascular hemorrhages. (See related article at e00679-19.) (Courtesy of Nanna Elmstedt Bild, Technical University of Denmark; reprinted with permission.)