Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Infection and Immunity
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

Table of Contents

August 2020; Volume 88,Issue 8

Spotlight

  • Free
    Articles of Significant Interest in This Issue
    Spotlight
    Articles of Significant Interest in This Issue

Minireview

  • The Potential Role of Schistosome-Associated Factors as Therapeutic Modulators of the Immune System
    Minireview
    The Potential Role of Schistosome-Associated Factors as Therapeutic Modulators of the Immune System

    The parasites and eggs of helminths, including schistosomes, are associated with factors that can modulate the nature and outcomes of host immune responses, particularly enhancing type 2 immunity and impairing the effects of type 1 and type 17 immunity. The main species of schistosomes that cause infection in humans are capable of generating a microenvironment that allows survival of the parasite by evasion of the immune response....

    Junhui Li, Hong Liu, Jie Jiang, Xingguo She, Ying Niu, Yingzi Ming

Molecular Pathogenesis

  • Open Access
    Genomic Profiling Reveals Distinct Routes To Complement Resistance in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Molecular Pathogenesis
    Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae

    The serum complement system is a first line of defense against bacterial invaders. Resistance to killing by serum enhances the capacity of Klebsiella pneumoniae to cause infection, but it is an incompletely understood virulence trait. Identifying and characterizing the factors responsible for preventing activation of, and killing by, serum complement could inform new...

    Francesca L. Short, Gianna Di Sario, Nathalie T. Reichmann, Colin Kleanthous, Julian Parkhill, Peter W. Taylor
  • <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases
    Molecular Pathogenesis
    Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases

    Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB and aureolysin in vitro, and that the ΔfakA mutant causes...

    Miranda J. Ridder, Seth M. Daly, Kathleen D. Triplett, Nichole A. Seawell, Pamela R. Hall, Jeffrey L. Bose

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

  • Innate Effector Systems in Primary Human Macrophages Sensitize Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> to Antibiotics
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Innate Effector Systems in Primary Human Macrophages Sensitize Multidrug-Resistant Klebsiella pneumoniae to Antibiotics

    Infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae are difficult to treat with conventional antibiotics. Thus, alternative strategies to control the growth of MDR Klebsiella are warranted. We hypothesized that activation of innate effector systems could sensitize MDR K. pneumoniae to conventional antibiotics. Thus, human primary...

    Rokeya Sultana Rekha, Harpa Karadottir, Sultan Ahmed, Gudmundur H. Gudmundsson, Birgitta Agerberth, Peter Bergman
  • <span class="named-content genus-species" id="named-content-1">Legionella pneumophila</span> Excludes Autophagy Adaptors from the Ubiquitin-Labeled Vacuole in Which It Resides
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | Spotlight
    Legionella pneumophila Excludes Autophagy Adaptors from the Ubiquitin-Labeled Vacuole in Which It Resides

    Xenophagy targets intracellular pathogens for destruction by the host autophagy pathway. Ubiquitin chains are conjugated to xenophagic targets and recruit multiple autophagy adaptors. The intracellular pathogen Legionella pneumophila resides in a vacuole that is ubiquitinated; however, this pathogen avoids xenophagic detection. Here, the mechanisms by which...

    Titilayo O. Omotade, Craig R. Roy

Bacterial Infections

  • Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence
    Bacterial Infections
    Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence

    Colonization by pathogenic bacteria depends on their ability to overcome host nutritional defenses and acquire nutrients. The human pathogen group A streptococcus (GAS) encounters the host defense factor calprotectin (CP) during infection. CP inhibits GAS growth in vitro by imposing zinc (Zn) limitation. However, GAS counterstrategies to combat CP-mediated Zn limitation and the in vivo relevance of CP-GAS interactions...

    Nishanth Makthal, Hackwon Do, Brian M. Wendel, Randall J. Olsen, John D. Helmann, James M. Musser, Muthiah Kumaraswami
  • The <em>uroS</em> and <em>yifB</em> Genes Conserved among Tetrapyrrole Synthesizing-Deficient <em>Bacteroidales</em> Are Involved in <span class="named-content genus-species" id="named-content-1">Bacteroides fragilis</span> Heme Assimilation and Survival in Experimental Intra-abdominal Infection and Intestinal Colonization
    Bacterial Infections
    The uroS and yifB Genes Conserved among Tetrapyrrole Synthesizing-Deficient Bacteroidales Are Involved in Bacteroides fragilis Heme Assimilation and Survival in Experimental Intra-abdominal Infection and Intestinal Colonization

    The human intestinal anaerobic commensal and opportunistic pathogen Bacteroides fragilis does not synthesize the tetrapyrrole protoporphyrin IX in order to form heme that is required for growth stimulation and survival in vivo. Consequently, B. fragilis acquires essential heme from host...

    Anita C. Parker, Hector A. Bergonia, Nathaniel L. Seals, Cecile L. Baccanale, Edson R. Rocha
  • The <span class="named-content genus-species" id="named-content-1">Serratia marcescens</span> Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection
    Bacterial Infections | Spotlight
    The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection

    Serratia marcescens is a bacterium frequently found in the environment, but over the last several decades it has evolved into a concerning clinical pathogen, causing fatal bacteremia. To establish such infections, pathogens require specific nutrients; one very limited but essential nutrient is iron. We sought to characterize the iron acquisition systems in...

    Danelle R. Weakland, Sara N. Smith, Bailey Bell, Ashootosh Tripathi, Harry L. T. Mobley

Host Response and Inflammation

  • <em>mcr-1</em> Gene Expression Modulates the Inflammatory Response of Human Macrophages to <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Host Response and Inflammation
    mcr-1 Gene Expression Modulates the Inflammatory Response of Human Macrophages to Escherichia coli

    MCR-1 is a plasmid-encoded phosphoethanolamine transferase able to modify the lipid A structure. It confers resistance to colistin and was isolated from human, animal, and environmental strains of Enterobacteriaceae, raising serious global health concerns. In this paper, we used recombinant mcr-1-expressing Escherichia coli to study the impact of MCR...

    Giorgio Mattiuz, Sabrina Nicolò, Alberto Antonelli, Tommaso Giani, Ilaria Baccani, Antonio Cannatelli, Ann Maria Clemente, Giuseppe Castronovo, Michele Tanturli, Federico Cozzolino, Gian Maria Rossolini, Maria Gabriella Torcia
  • <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span> Clearance by Neutrophils Is Independent of Autophagy
    Host Response and Inflammation
    Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy

    Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, is increasingly prevalent in chronic lung disease, including cystic fibrosis, and infections are characterized by neutrophil-dominated environments. However, mechanisms of immune control are poorly understood. Azithromycin, a macrolide antibiotic with immunomodulatory effects, is used to treat...

    Kerstin Pohl, Xue A. Grimm, Silvia M. Caceres, Katie R. Poch, Noel Rysavy, Milene Saavedra, Jerry A. Nick, Kenneth C. Malcolm
  • <em>Salmonella</em> Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment
    Host Response and Inflammation | Spotlight
    Salmonella Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment

    The intracellular bacterial pathogen Salmonella is able to evade the immune system and persist within the host. In some cases, these persistent infections are asymptomatic for long periods and represent a significant public health hazard because the hosts are potential chronic carriers, yet the mechanisms that control persistence are incompletely understood. Using a...

    Jonathan R Kurtz, Wildaliz Nieves, David L. Bauer, Kate E. Israel, Haley E. Adcox, John S. Gunn, Lisa A. Morici, James B. McLachlan
  • Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Host Response and Inflammation
    Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum

    Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood...

    Tatiana Hountohotegbe, Komi Gbedande, Gino Agbota, Samad Ibitokou, Achille Massougbodji, Philippe Deloron, Nadine Fievet, Adrian J. F. Luty
  • Open Access
    NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of <span class="named-content genus-species" id="named-content-1">Caenorhabditis elegans</span> during <span class="named-content genus-species" id="named-content-2">Enterococcus faecalis</span> Infection
    Host Response and Inflammation
    NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection

    Immune response to pathogens is energetically expensive to the host; however, the cellular source of energy to fuel immune response remains unknown. In this study, we show that Caenorhabditis elegans exposed to pathogenic Gram-positive and Gram-negative bacteria or yeast rapidly utilizes lipid droplets, the major energy reserve. The nematode’s response to the...

    Madhumanti Dasgupta, Meghana Shashikanth, Anjali Gupta, Anjali Sandhu, Atreyee De, Salil Javed, Varsha Singh
  • <em>Chlamydia</em> Lipooligosaccharide Has Varied Direct and Indirect Roles in Evading both Innate and Adaptive Host Immune Responses
    Host Response and Inflammation
    Chlamydia Lipooligosaccharide Has Varied Direct and Indirect Roles in Evading both Innate and Adaptive Host Immune Responses

    Chlamydia bacteria are obligate intracellular pathogens which can cause a variety of disease in humans and other vertebrate animals. To successfully complete its life cycle, Chlamydia must evade both intracellular innate immune responses and adaptive cytotoxic T cell responses. Here, we report on the role of the chlamydial lipooligosaccharide (LOS) in evading the immune response. Chlamydia infection is known...

    Xisheng Wang, Daniel D. Rockey, Brian P. Dolan

Fungal and Parasitic Infections

  • <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span> Evades Pulmonary Immunity by Modulating Xylose Precursor Transport
    Fungal and Parasitic Infections | Spotlight
    Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport

    Cryptococcus neoformans is a fungal pathogen that kills almost 200,000 people each year and is distinguished by abundant and unique surface glycan structures that are rich in xylose. A mutant strain of C. neoformans that cannot transport xylose precursors into the secretory compartment is severely...

    Lucy X. Li, Camaron R. Hole, Javier Rangel-Moreno, Shabaana A. Khader, Tamara L. Doering
  • Morphological and Motility Features of the Stable Bleb-Driven Monopodial Form of <em>Entamoeba</em> and Its Importance in Encystation
    Fungal and Parasitic Infections
    Morphological and Motility Features of the Stable Bleb-Driven Monopodial Form of Entamoeba and Its Importance in Encystation

    Entamoeba histolytica and its reptilian counterpart and encystation model Entamoeba invadens formed a polarized monopodial morphology when treated with pentoxifylline. This morphology was propelled by retrograde flow of the cell surface resulting from a cyclic sol-gel conversion of cytoplasm and a...

    Deepak Krishnan, Sudip Kumar Ghosh

Microbial Immunity and Vaccines

  • Progress towards the Development of a NEAT Vaccine for Anthrax II: Immunogen Specificity and Alum Effectiveness in an Inhalational Model
    Microbial Immunity and Vaccines
    Progress towards the Development of a NEAT Vaccine for Anthrax II: Immunogen Specificity and Alum Effectiveness in an Inhalational Model

    Bacillus anthracis is the causative agent of anthrax disease, presents with high mortality, and has been at the center of bioweapon efforts. The only currently U.S. FDA-approved vaccine to prevent anthrax in humans is anthrax vaccine adsorbed (AVA), which is protective in several animal models and induces neutralizing antibodies against protective antigen (PA), the...

    Joseph Jelinski, Austen Terwilliger, Sabrina Green, Anthony Maresso

Masthead

  • Free
    Editorial Board
    Masthead
    Editorial Board
PreviousNext
Back to top

Infection and Immunity: 88 (8)

In This Issue

volume 88, issue 8
  • Table of Contents (PDF)
  • Journal Cover & Description

Issue Spotlights

  • Articles of Significant Interest in This Issue
Sign up for alerts

Jump to

  • Spotlight
  • Minireview
  • Molecular Pathogenesis
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
  • Bacterial Infections
  • Host Response and Inflammation
  • Fungal and Parasitic Infections
  • Microbial Immunity and Vaccines
  • Masthead
  • Most Read
  • Most Cited
Loading
  • Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies
  • Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia
  • Eukaryotic SNARE VAMP3 Dynamically Interacts with Multiple Chlamydial Inclusion Membrane Proteins
  • The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague
More...

About

  • About IAI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #IAIjournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0019-9567; Online ISSN: 1098-5522