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Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections

Shaunna R. Simmons, Manmeet Bhalla, Sydney E. Herring, Essi Y. I. Tchalla, Elsa N. Bou Ghanem
Anthony R. Richardson, Editor
Shaunna R. Simmons
aDepartment of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA
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Manmeet Bhalla
aDepartment of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA
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Sydney E. Herring
aDepartment of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA
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Essi Y. I. Tchalla
aDepartment of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA
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Elsa N. Bou Ghanem
aDepartment of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA
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  • ORCID record for Elsa N. Bou Ghanem
Anthony R. Richardson
University of Pittsburgh
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DOI: 10.1128/IAI.00653-20
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ABSTRACT

Elderly individuals are at increased risk of life-threatening pulmonary infections. Neutrophils are a key determinant of the disease course of pathogen-induced pneumonia. Optimal host defense balances initial robust pulmonary neutrophil responses to control pathogen numbers, ultimately followed by the resolution of inflammation to prevent pulmonary damage. Recent evidence suggests that phenotypic and functional heterogeneity in neutrophils impacts host resistance to pulmonary pathogens. Apart from their apparent role in innate immunity, neutrophils also orchestrate subsequent adaptive immune responses during infection. Thus, the outcome of pulmonary infections can be shaped by neutrophils. This review summarizes the age-driven impairment of neutrophil responses and the contribution of these cells to the susceptibility of the elderly to pneumonia. We describe how aging is accompanied by changes in neutrophil recruitment, resolution, and function. We discuss how systemic and local changes alter the neutrophil phenotype in aged hosts. We highlight the gap in knowledge of whether these changes in neutrophils also contribute to the decline in adaptive immunity seen with age. We further detail the factors that drive dysregulated neutrophil responses in the elderly and the pathways that may be targeted to rebalance neutrophil activity and boost host resistance to pulmonary infections.

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Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections
Shaunna R. Simmons, Manmeet Bhalla, Sydney E. Herring, Essi Y. I. Tchalla, Elsa N. Bou Ghanem
Infection and Immunity Mar 2021, 89 (4) e00653-20; DOI: 10.1128/IAI.00653-20

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Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections
Shaunna R. Simmons, Manmeet Bhalla, Sydney E. Herring, Essi Y. I. Tchalla, Elsa N. Bou Ghanem
Infection and Immunity Mar 2021, 89 (4) e00653-20; DOI: 10.1128/IAI.00653-20
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • AGE-DRIVEN CHANGES IN NEUTROPHIL RESPONSES
    • NEUTROPHIL PHENOTYPES IN AGED HOSTS
    • THE ROLE OF NEUTROPHILS BEYOND INNATE IMMUNITY
    • APPROACHES FOR REVERSING DYSREGULATED PMN RESPONSES IN AGING
    • SUMMARY AND FUTURE PERSPECTIVES
    • ACKNOWLEDGMENTS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

neutrophils
aging
pneumonia
lung infections
immunosenescence

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