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Getting Your Neutrophil: Neutrophil Transepithelial Migration in the Lung

Walter Adams, Taylor Espicha, Janine Estipona
Karen M. Ottemann, Editor
Walter Adams
aDepartment of Biological Sciences, San Jose State University, San Jose, California, USA
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Taylor Espicha
aDepartment of Biological Sciences, San Jose State University, San Jose, California, USA
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Janine Estipona
aDepartment of Biological Sciences, San Jose State University, San Jose, California, USA
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Karen M. Ottemann
University of California, Santa Cruz
Roles: Editor
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DOI: 10.1128/IAI.00659-20
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ABSTRACT

Neutrophil transepithelial migration is a fundamental process that facilitates the rapid trafficking of neutrophils to inflammatory foci and occurs across a diverse range of tissues. For decades, there has been widespread interest in understanding the mechanisms that drive this migratory process in response to different pathogens and organ systems. This has led to the successful integration of key findings on neutrophil transepithelial migration from the intestines, lungs, liver, genitourinary tract, and other tissues into a single, cohesive model. However, recent studies have identified organ-specific differences in neutrophil transepithelial migration. These findings support a model where the tissue in concert with the proinflammatory stimuli dictates a unique collection of signals that drive neutrophil trafficking. This review focuses on the mechanisms that drive neutrophil transepithelial migration in response to microbial infection of a single organ, the lung. Herein, we provide a detailed analysis of the adhesion molecules and chemoattractants that contribute to the recruitment of neutrophils into the airways. We also highlight important advances in experimental models for studying neutrophil transepithelial migration in the lung over the last decade.

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Getting Your Neutrophil: Neutrophil Transepithelial Migration in the Lung
Walter Adams, Taylor Espicha, Janine Estipona
Infection and Immunity Mar 2021, 89 (4) e00659-20; DOI: 10.1128/IAI.00659-20

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Getting Your Neutrophil: Neutrophil Transepithelial Migration in the Lung
Walter Adams, Taylor Espicha, Janine Estipona
Infection and Immunity Mar 2021, 89 (4) e00659-20; DOI: 10.1128/IAI.00659-20
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • THE LUNG EPITHELIUM: A BRIEF OVERVIEW
    • NEUTROPHIL AND EPITHELIAL ADHESION MOLECULES
    • NEUTROPHIL CHEMOATTRACTANTS
    • NEW MODELS FOR STUDYING NEUTROPHIL TEpM
    • CONCLUSIONS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

neutrophil
transepithelial migration
adhesion molecules
chemoattractants
lung
neutrophils
polarized epithelia

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