RT Journal Article
SR Electronic
T1 Effect of Vaccination with Carrier Protein on Response to Meningococcal C Conjugate Vaccines and Value of Different Immunoassays as Predictors of Protection
JF Infection and Immunity
JO Infect. Immun.
FD American Society for Microbiology
SP 4946
OP 4954
DO 10.1128/IAI.70.9.4946-4954.2002
VO 70
IS 9
A1 Burrage, Moya
A1 Robinson, Andrew
A1 Borrow, Ray
A1 Andrews, Nick
A1 Southern, Joanna
A1 Findlow, Jamie
A1 Martin, Sarah
A1 Thornton, Carol
A1 Goldblatt, David
A1 Corbel, Michael
A1 Sesardic, Dorothea
A1 Cartwight, Keith
A1 Richmond, Peter
A1 Miller, Elizabeth
YR 2002
UL http://iai.asm.org/content/70/9/4946.abstract
AB In order to plan for the wide-scale introduction of meningococcal C conjugate (MCC) vaccine for United Kingdom children up to 18 years old, phase II trials were undertaken to investigate whether there was any interaction between MCC vaccines conjugated to tetanus toxoid (TT) or a derivative of diphtheria toxin (CRM197) and diphtheria-tetanus vaccines given for boosting at school entry or leaving. Children (n = 1,766) received a diphtheria-tetanus booster either 1 month before, 1 month after, or concurrently with one of three MCC vaccines conjugated to CRM197 or TT. All of the MCC vaccines induced high antibody responses to the serogroup C polysaccharide that were indicative of protection. The immune response to the MCC-TT vaccine was reduced as a result of prior immunization with a tetanus-containing vaccine, but antibody levels were still well above the lower threshold for protection. Prior or simultaneous administration of a diphtheria-containing vaccine did not affect the response to MCC-CRM197 vaccines. The immune responses to the carrier proteins were similar to those induced by a comparable dose of diphtheria or tetanus vaccine. The results also demonstrate that, for these conjugate vaccines in these age groups, both standard enzyme-linked immunosorbent assays and those that measure high-avidity antibodies to meningococcal C polysaccharide correlated equally well with assays that measure serum bactericidal antibodies, the established serological correlate of protection for MCC vaccines.