RT Journal Article
SR Electronic
T1 T-cell cytokine responses in human infection with Mycobacterium tuberculosis.
JF Infection and Immunity
JO Infect. Immun.
FD American Society for Microbiology
SP 3231
OP 3234
VO 63
IS 8
A1 Zhang, M
A1 Lin, Y
A1 Iyer, D V
A1 Gong, J
A1 Abrams, J S
A1 Barnes, P F
YR 1995
UL http://iai.asm.org/content/63/8/3231.abstract
AB Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.