TABLE 2.

Reactivities of antigenic peptides of PPE-C with sera from TB patientsa

Disease status (no. of patients)No. (%) of patients with antibodies to:No. (%) of PPE-C antibody-positive patients with antibodies to:P valueb
PPE-C proteinPPE-C1 peptidePPE-C2 peptidePPE-C1 and/or PPE-C2 peptidesPPE-C1 and/or PPE-C2 peptidesPPE-C1 peptidePPE-C2 peptide
HIV+ subclinical TB (21)17 (81)6 (29)12 (57)12 (57)11 (65)5 (45)11 (100)0.0351
HIV+ TB+(24)17 (71)11 (46)12 (50)15 (63)12 (71)9 (75)10 (83)0.0104
HIV TB+ (30)29 (97)17 (57)16 (53)20 (67)20 (69)17 (85)16 (80)0.0086
  • a The presence of antibodies to PPE-C and peptides PPE-C1 and PPE-C2 in sera from TB patients and PPD+/PPD healthy controls was determined by ELISA. The mean OD plus 3 SD obtained with healthy controls was used as the cutoff to determine positive responses in patients.

  • b Correlation between the presence of antibodies to PPE-C1 and PPE-C2, as determined by the Fisher test.