TABLE 3.

Virulence of pmt mutants in a mouse model of hematogenously disseminated infection

C. albicans strainaRelevant genotypeMean survival time (days)No. of dead mice/total no.b
SPCa2 pmt1/pmt1 >60c0/6
SPCa3 pmt1/pmt1 >60c0/6
SPCa4 pmt2/PMT2 >60c0/6
SPCa5 pmt2/PMT2 >60c0/6
SPCa6 pmt4/pmt4 3.5d6/6
SPCa7 pmt4/pmt4 6.5c6/6
SPCa10 pmt5/pmt5 4d6/6
SPCa11 pmt5/pmt5 3.5d6/6
SPCa8 pmt6/pmt6 3d6/6
SPCa9 pmt6/pmt6 3d6/6
CAF2-1Wild type26/6
  • a CD2F1 mice were infected intravenously with 1 × 106C. albicans cells.

  • b The results were determined after 60 days.

  • c P < 0.01 for a comparison of a pmt mutant and the wild-type strain.

  • d P < 0.05 for a comparison of a pmt mutant and the wild-type strain.