Survival of piglets treated i.p. with 5C12 antibody or control after oral challenge with STEC 86-24, an Stx2 producera

Treatment typeAntibody concn (mg/kg)Total no. of pigletsNo. (%) of surviving pigletsbSerum IgG1(κ) concn (μg/ml)c
5C12397 (78)4.4 ± 1.0
IgG1κ380 (0)9.2 ± 2.5
PBS021 (50)0
5C121.586 (75)3.1 ± 1.8
PBS070 (0)0
  • a Irrelevant human IgG(κ) or PBS was used as the control. Challenge was with 1010 CFU of STEC 86-24.

  • b Piglets were either euthanized due to severe CNS-related illness or found dead.

  • c Results reflect the concentration in serum of the human IgG1(κ) isotype, which is the isotype of 5C12. Values are means ± standard deviations.