TABLE 5.

Serum antibody responses to CS1 or CS3 measured by TRF ELISA after one or two doses of PTL-002 or PTL-003a

AntibodyVaccineNo. of respondersb (%)Total no. of respondersb (%)Pc
One-dose groupTwo-dose group
Anti-CS1
    IgAPTL-0023/10 (30)3/10 (30)6/20 (30)0.11
PTL-0035/9 (56)6/11 (55)11/20 (55)
    IgGPTL-0020/10 (0)2/10 (20)2/20 (10)0.66
PTL-0031/9 (11)3/11 (27)4/20 (20)
Anti-CS3
    IgAPTL-0022/10 (20)3/10 (30)5/20 (25)0.03
PTL-0037/9 (78)6/11 (55)13/20 (65)
    IgGPTL-0020/10 (0)2/10 (20)2/20 (10)0.03
PTL-0034/9 (44)5/11 (45)9/20 (45)
Anti-CS1 or anti-CS3
    IgAPTL-0023/10 (30)4/10 (40)7/20 (35)0.03
PTL-0037/9 (78)8/11 (73)15/20 (75)
    IgGPTL-0020/10 (0)3/10 (30)3/20 (15)0.02
PTL-0034/9 (44)7/11 (64)11/20 (55)
  • a Antibody levels were measured by time-resolved fluorescence. Response was defined as ≥2-fold increase compared to preimmune levels.

  • b Number of subjects with a response/total number of subjects in group (%).

  • c Chi-square or Fisher's exact test comparison of total responders to PTL-002 versus total responders to PTL-003.