TABLE 1.

Vaccine antigen-specific Th1/Th2 ratios in PBMC-DC cocultures from 12-month-old children and adults

RatioMedian (interquartile range)a
12-mo-old childrenAdults
Diphtheria toxoidTetanus toxoidDiphtheria toxoidTetanus toxoid
IFN-γ/IL-50.2 (0.1-1.0)0.4 (0.1-1.6)55.2b (3.6-196.5)25.8b (2.3-40.3)
IFN-γ/IL-130.4 (0.1-1.7)0.1 (0.0-1.2)19.9c (1.5-32.5)6.8b (1.7-18.1)
  • a The IFN-γ/IL-5 and IFN-γ/IL-13 ratios were calculated for each individual. The statistical significance of differences between 12-month-old children and adults was assessed using the Mann-Whitney U test.

  • b P = 0.001 compared to value for 12-month-old children.

  • c P = 0.004 compared to value for 12-month-old children.