TABLE 1.

Pulmonary Th1/Th2, inflammatory cytokine, and chemokine levelsa

Cytokine or chemokineLevel (pg/ml) in pulmonary homogenate tissue at day:
37
H99H99 IFN-γH99H99 IFN-γ
Th1-type cytokine
    IFN-γ118.8 ± 27104.1 ± 27188.6 ± 27.51,426 ± 122.5*
    IL-2143.7 ± 22.5171.4 ± 17.8363.5 ± 42.5582.9 ± 51.9*
    IL-12 p40262.6 ± 17.4277.3 ± 35.4427.5 ± 33.8988.5 ± 118*
    IL-12 p70101.6 ± 11.3133.6 ± 28.3222.9 ± 14.3425.7 ± 48.3*
Th2-type cytokine
    IL-49.8 ± 2.27 ± 0.6104.6 ± 11.9*56.9 ± 4.2
    IL-5312.4 ± 45.099.15 ± 26.81,031 ± 109.1*347.9 ± 39.2
Inflammatory cytokine
    IL-1α195.5 ± 19.3252.4 ± 38.5398.1 ± 18.9665.8 ± 92.2*
    IL-17223 ± 25.5378.1 ± 70.8467.9 ± 21.81,361 ± 100.4*
    TNF-α132.3 ± 42.1160.7 ± 47.3167.1 ± 31.9541 ± 159.1*
    G-CSF436.4 ± 51.6590.4 ± 120.1961.1 ± 78.61,324 ± 115.6*
Chemokine
    MIP-1α648.1 ± 80719.2 ± 112.31,838 ± 1793,018 ± 428.4*
    RANTES542.6 ± 65.4546.9 ± 62.371,008 ± 75.81,652 ± 189.1*
  • a *, P < 0.05 compared to the infected counterpart on the same day postinoculation.