TABLE 1.

Liver parasitism in the acute phase of T. cruzi infectiona

No. of days p.i.No. of amastigote nests/liver slide in mouse strain:
WTIFN-γ KOCD4 KOCD8 KO
9ND1.4 ± 1.2NDND
130.2 ± 0.3>50.09.8 ± 3.812.3 ± 3.0
16ND0.3 ± 0.51.2 ± 2.1
20ND0.3 ± 0.51.2 ± 1.3
  • a Wild-type and deficient mice infected by Y strain T. cruzi parasites were sacrificed at the indicated days, and their livers were analyzed for the presence of amastigote nests. Results represent the mean (±SD) amastigote nests of six non-consecutive hematoxilin-eosin stained slides, for each mouse, for five mice from each group and time point. Results from a representative experiment out of two experiments are shown. ND, not detected.