Table 2.

Effect of iron chelation on oxidant-mediated endothelial cell damage

TreatmentEndothelial cell damage (median % specific release of 51Cr)a by:
C. albicansb XO-HXc
Control39.7 (35.3–42.6)27.4 (20.7–35.3)
Catalase37.8 (34.3–41.4)−0.1 (−0.9–0.5)d
SOD38.4 (35.3–41.4)22.7 (12.6–23.7)e
DMTU35.2 (33.8–39.4)4.2 (0.5–15.7)d
DMPO43.3 (39.2–45.2)11.3 (5.6–17.4)d
Allopurinol31.5 (24.7–32.8)11.5 (0.8–15.7)d
Mannitol47.5 (44.2–49.5)15.5 (13.2–16.4)e
BSO40.2 (36.8–41.7)32.2 (24.9–51.5)e
Deferoxamine20.7 (17.0–21.4)d 7.9 (3.2–10.3)d
Phenanthroline (1 h)38.3 (33.9–40.7)11.8 (7.3–19.2)d
Phenanthroline (24 h)7.6 (5.4–9.9)d 52.6 (37.6–61.6)e
  • a The numbers in parentheses indicate the first to third quartiles.

  • b Endothelial cells were incubated for 3 h with 106 C. albicans blastospores/ml.

  • c Endothelial cells were incubated for 5 h with 5 mU of XO per ml and 1 mM HX.

  • d P < 0.001 versus the control.

  • e P = 0.05 versus the control.