TABLE 3.

Numbers of BALB/cCrSlc wild-type mice (genotype +/+) and H+,K+-ATPase β-subunit-deficient transgenic mice (genotype −/−) colonized with Y. enterocolitica, S. enterica serovar Typhimurium, and C. rodentium 3 days after oral infection and ID50s

SpeciesDose (CFU)aNo. of mice containing >103 CFU per g of tissue/no. of mice tested (%)b
Genotype +/+ miceGenotype −/− mice
Y. enterocolitica 1087/7 (100)8/8 (100)
1074/5 (80)7/7 (100)
1062/7 (29)4/7 (57)
1050/8 (0)2/8 (25)
S. enterica serovar Typhimurium1089/10 (90)c9/9 (100)
1073/8 (38)9/9 (100)d,e
1063/8 (38)8/8 (100)e
1051/8 (13)4/8 (50)
C. rodentium 1087/7 (100)7/7 (100)
1070/7 (0)4/8 (50)
1060/9 (0)3/8 (38)
  • a For BALB/cCrSlc wild-type mice (genotype +/+) the ID50s of Y. enterocolitica, S. enterica serovar Typhimurium, and C. rodentium were 106.41, 106.85, and 107.5 CFU, respectively; for H+,K+-ATPase β-subunit-deficient transgenic mice (genotype −/−) the ID50s of these organisms were 105.65, 105, and 107 CFU, respectively.

  • b Bacteria were retrieved from the small intestine of mice infected with Y. enterocolitica or S. enterica serovar Typhimurium and from the cecum of mice infected with C. rodentium.

  • c Including one mouse that succumbed to the infection.

  • d Including two mice that succumbed to the infection.

  • e P < 0.05, as determined by two-tailed Fisher's exact test.