TABLE 3.

Genes down-regulated during acute cholera

Affymetrix IDMean log2 ratioaNo. of patientsbGeneGene productSubcellular localizationc
205749_at−2.735CYP1A1Cytochrome P-450, 1A1M, Li
238245_at−1.776ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7M, Li
222938_x_at−1.746ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3M
244044_at
232737_s_at
204450_x_at−1.706APOA1Apolipoprotein A-IS, Li
217073_x_at
229725_at−1.466ACSL6Long-chain acyl-coenzyme A synthetase 6M, Li
231416_at−1.465DHDHDimeric dihydrodiol dehydrogenaseC
241811_x_at−1.466ESTd (GenBank accession no. BE645279)
205820_s_at−1.436APOC3Apolipoprotein C-IIIS, Li
244014_x_at−1.415EST (GenBank accession no. BF433962)
239229_at−1.416EST (GenBank accession no. AI342246)
1555338_s_at−1.406AQP10Aquaporin 10M
242009_at−1.366EST (GenBank accession no. AI082692)
204561_x_at−1.347APOC2Apolipoprotein C-IIS, Li
1552279_a_at−1.306Hypothetical protein FLJ00234
206292_s_at−1.236SULT2A1Alcohol sulfotransferaseC, Li
206293_at
223579_s_at−1.216APOBApolipoprotein BS, Li
224412_s_at−1.215TRPM6Transient receptor potential cation channel M6M
228377_at−1.205KLHL14Kelch-like 14
210096_at−1.175CYP4B1Cytochrome P-450, 4B1M, Li
227480_at−1.166SUSD2Sushi domain containing 2M
207519_at−1.167SLC6A4Solute carrier family 6A4M
1553486_a_at−1.166Hypothetical protein FLJ39647
1556250_at−1.165ST18Suppression of tumorigenicity 18N
223732_at−1.136SLC23A1Solute carrier 23A1M
207885_at−1.095S100GCalbindin D9kC
220851_at−1.095Hypothetical protein PRO1600
207378_at−1.065TREHTrehalase (brush border membrane glycoprotein)M
229793_at−1.066EST (GenBank accession no. AI656964)
1552362_a_at−1.065LEAP-2Liver-expressed antimicrobial peptide 2S
205939_at−1.045CYP3A7Cytochrome P-450, 3A7M, Li
207362_at−1.045SLC30A4Solute carrier family 30A4M
207125_at−1.015ZNF225Zinc finger protein 225N
1558703_at−1.006Hypothetical protein DKFZp451K1917
  • a The log2 ratios are the acute-phase/convalescent-phase ratios.

  • b Number of patients that showed differential expression resulting in a log2 ratio of <0.5.

  • c S, secreted; M, membrane associated; C, cytosolic; N, nuclear; Li, involved in the metabolism or transport of lipids.

  • d EST, expressed sequence tag.