TABLE 1

KEGG pathways overrepresented in the differentially expressed gene lists highlight similarities and differences in response of bMDM to infection with M. bovis strainsa

Common KEGG pathwayStrain-specific pathway
AF2122G18
2 h
    NOD-like receptor signaling pathwayCAMsB cell receptor signaling pathway
    Cytokine-cytokine receptor interactionMAPK signaling pathway
    Toll-like receptor signaling pathway
    Chemokine signaling pathway
    RIG-I-like receptor signaling pathway
    Jak-STAT signaling pathway
    T cell receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Apoptosis
    Hematopoietic cell lineage
    Natural killer cell-mediated cytotoxicity
    Adipocytokine signaling pathway
6 h
    Cytokine-cytokine receptor interactionp53 signaling pathwayFc gamma R-mediated phagocytosis
    NOD-like receptor signaling pathway
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway
    RIG-I-like receptor signaling pathway
    Apoptosis
    B cell receptor signaling pathway
    Adipocytokine signaling pathway
    Cytosolic DNA-sensing pathway
    T cell receptor signaling pathway
    Hematopoietic cell lineage
    Natural killer cell-mediated cytotoxicity
    CAMs
    MAPK signaling pathway
    Fc epsilon RI signaling pathway
    Leukocyte transendothelial migration
24 h
    Cytokine-cytokine receptor interactionComplement and coagulation cascades
    Chemokine signaling pathway
    Cytosolic DNA-sensing pathway
    NOD-like receptor signaling pathway
    Toll-like receptor signaling pathway
    Hematopoietic cell lineage
48 h
    Cytokine-cytokine receptor interactionECM-receptor interactionCytosolic DNA-sensing pathway
    NOD-like receptor signaling pathwayToll-like receptor signaling pathway
    Hematopoietic cell lineageRIG-I-like receptor signaling pathway
    Chemokine signaling pathwayComplement and coagulation cascades
    CAMs
  • a Overrepresented KEGG pathways were identified using the online Database for Annotation, Visualization and Integrated Discovery (DAVID) using a cutoff P value of <0.05. CAMs, cell adhesion molecules.