TABLE 1.

Response to experimental inoculation of H. ducreyi 35000HP, 35000HPncaA, and 35000HPncaA merodiploid in pigs

StrainH. ducreyi CFU per lesion biopsya at day p.i.:% H. ducreyi-positive biopsiesb at day p.i.:
2727
35000HP161.0 (90.5-497.4)146.8 (111.2-320.8)60.3 (30.9-75.7)72.9 (57.5-96.8)
35000HPncaA30.4 (19.5-82.3)c6.1 (2.2-28.6)c56.4 (31.6-68.7)20.0 (17.1-61.7)c
35000HPncaA merodiploid280.9 (181.0-1390.2)320.3 (148.3-1080.7)70.0 (24.9-85.4)75.0 (64.3-95.7)
  • a Values indicate the observed mean CFU per biopsy, with 95% confidence intervals in parentheses, as modeled by poisson regression and GEE adjustment to account for variability between pigs.

  • b Values indicate the observed mean proportion of biopsies harboring viable H. ducreyi, with 95% confidence intervals in parentheses, as modeled by logistic regression and GEE adjustment.

  • c Significantly different (P < 0.0001) from values for wild-type or merodiploid lesions on same day postinoculation.