TABLE 1.

Analysis of serum and lung wash samples following intratracheal administration of MAbs 7.3 and F1-04-A-G1

MouseTreatmentaAmt of MAb (ng ml−1)b
7.3F1-04-A-G1
SerumLung washSerumLung wash
1PBSNDNDNDND
2PBSNDNDNDND
315.5 μg MAb1,631ND882ND
415.5 μg MAb1857720
515.5 μg MAb5104330
615.5 μg MAb284ND377ND
777.5 μg MAb586ND872ND
877.5 μg MAb671ND634ND
  • a MAb 7.3 (15.5 or 77.5 μg in 50 μl PBS) and MAb F1-04-A-G1 (15.5 or 77.5 μg in 50 μl PBS) or PBS was delivered as a spray to the lungs of anesthetized mice by means of the PenCentuary device.

  • b Amount of MAb 7.3 or MAb F1-04-A-G1 in mouse serum and lung wash samples 2 h posttreatment. ND, none detected.