TABLE 1

EHEC, EPEC, and Shigella effectors that modulate the NF-κB pathway

Effector(s)Encoding organismsHost target(s)ActivityReference(s)
NleBA/E pathogensTRADD, FADD, RIPK1Glycosyltransferase3743
EspLA/E pathogensRIPK1, RIPK3Cysteine protease45
OspIShigella spp.Ubc13Deamidase4648
IpaH1.4Shigella spp.HOIPE3 ubiquitin ligase19, 52
NleE, OspZA/E pathogens, Shigella spp.TAB2, TAB3Methyltransferase3738, 5962
OspGShigella spp.UnknownKinase6568
NleH1/2A/E pathogensCRKLKinase6971, 7374
NleCA/E pathogensNF-κB (p65)Zinc protease11, 7578, 80, 8284