TABLE 2.

Top 50 genes expressed by E. coli 83972 in vivo in patients

GeneCodeFunction or productSignal intensityaMember of top 50 genes expressed in urineMember of top 50 genes expressed in MOPS
rplEb330850S ribosomal subunit protein L53,788++
rrfHb02055S rRNA3,554++
t44b4414Small toxic membrane polypeptide3,508++
rplJb398550S ribosomal subunit protein L103,493++
csrBb4408CsrB regulatory RNA3,462++
cspCb1823Cold shock protein3,445
rpsKb329730S ribosomal subunit protein S113,437++
ahpCb0605Alkyl hydroperoxide reductase3,418+
rrsGb259116S rRNA3,244+
rpsHb330630S ribosomal subunit protein S83,222++
tufAb3339Protein chain elongation factor EF-Tu3,185++
rpsDb329630S ribosomal subunit protein S43,182++
rplXb330950S ribosomal subunit protein L243,166++
rpoAb3295RNA polymerase, alpha subunit3,128++
acpPb1094Acyl carrier protein3,068+
ompCc2758Outer membrane protein C precursor3,048++
rplNb331050S ribosomal subunit protein L143,043++
rpsMb329830S ribosomal subunit protein S133,037++
rplMb323150S ribosomal subunit protein L133,030++
ssrAb2621tmRNAb2,989+
infCZ2747Initiation factor IF-32,981+
rplCb332050S ribosomal subunit protein L32,977+
rnpBb3123RNase P, RNA component2,975+
rpsGb334130S ribosomal subunit protein S72,933++
rpmJb329950S ribosomal subunit protein L362,908+
enob2779Enolase2,894
rhoLb3782Rho operon leader peptide2,862
rplKb398350S ribosomal subunit protein L112,805++
yfiDb2579Stress-induced alternate pyruvate formate-lyase2,797
lppb1677Murein lipoprotein2,767++
folEb2153GTP cyclohydrolase I2,742+
aceEb0114Pyruvate dehydrogenase2,739+
rplLb398650S ribosomal subunit protein L7/L122,719++
rpsBb016930S ribosomal subunit protein S22,719+
c4310c4310Hypothetical protein2,714
csrCb4457CsrC regulatory RNA2,712
rplOb330150S ribosomal subunit protein L152,699++
ptsHb2415PTS family Hpr protein2,681
rplFb330550S ribosomal subunit protein L62,677++
rpmBb363750S ribosomal subunit protein L282,674
gapAb1779Glyceraldehyde-3-phosphate dehydrogenase A2,665
rpsLb334230S ribosomal subunit protein S122,665+
rplUb318650S ribosomal subunit protein L212,654
rpsNb330730S ribosomal subunit protein S142,648+
hupAb4000DNA-binding protein HU-alpha (HU-2)2,648+
gpmAb0755Phosphoglyceromutase 12,645+
fusAb3340GTP-binding protein chain elongation factor EF-G2,620++
rpsJb332130S ribosomal subunit protein S102,616+
yobFb1824Hypothetical protein2,565
rpsSb331630S ribosomal subunit protein S192,564+
  • a Signal intensities were calculated from all nine patient arrays treated as a single sample group. Values are model-based expression indexes calculated by dCHIP.

  • b tmRNA, transfer messenger RNA.