TABLE 3.

Expression of anti-inflammatory cytokines and mediators

mRNA from gene encoding indicated productExpression (mean ± SEM)a in:
LeukocytesGranulocytesMonocytes
ControlsPatientsControlsPatientsControlsPatients
IL-1RA0.307 ± 0.0210.730 ± 0.099***0.384 ± 0.0330.667 ± 0.071**0.234 ± 0.0210.560 ± 0.120***
IL-4 transcript variant 1NDbNDNDNDNDND
IL-4 transcript variant 20.011 ± 0.0010.093 ± 0.040***0.000 ± 0.0000.015 ± 0.005***0.000 ± 0.0000.048 ± 0.022***
IL-100.014 ± 0.0010.144 ± 0.001***0.006 ± 0.0060.014 ± 0.0050.000 ± 0.0000.015 ± 0.004***
IL-13NDNDNDNDNDND
TNF receptor superfamily 1A0.406 ± 0.0190.770 ± 0.058***0.280 ± 0.0310.553 ± 0.068**0.192 ± 0.0140.407 ± 0.064**
  • a Expression of inflammatory mRNAs from patients and control subjects in whole-blood leukocytes, granulocytes, and monocytes (normalized to B2M mRNA and in alphabetical order). P values are according to the Mann-Whitney test: **, P < 0.01; ***, P < 0.001 (versus controls).

  • b ND, not detectable.