TABLE 2.

Expression of proinflammatory cytokines and mediators

mRNA from gene encoding indicated productExpression (mean ± SEM)a in:
LeukocytesGranulocytesMonocytes
ControlsPatientsControlsPatientsControlsPatients
IFN-γ0.032 ± 0.0020.083 ± 0.022***NDbND0.027 ± 0.0030.020 ± 0.004
IL-12α0.069 ± 0.0030.145 ± 0.0400.034 ± 0.0060.010 ± 0.003**0.048 ± 0.0060.044 ± 0.007
IL-12βNDNDNDNDNDND
IL-15-R010.066 ± 0.0040.275 ± 0.046***0.013 ± 0.0030.110 ± 0.016***0.072 ± 0.0620.136 ± 0.012***
IL-15-R020.011 ± 0.0010.060 ± 0.016***NDND0.002 ± 0.0010.009 ± 0.003*
IL-1αNDNDNDNDNDND
IL-1β0.191 ± 0.0130.346 ± 0.030***0.153 ± 0.0140.236 ± 0.029*0.072 ± 0.0090.135 ± 0.031
IL-2NDNDNDNDNDND
IL-60.018 ± 0.0020.095 ± 0.046***0.000 ± 0.0000.018 ± 0.007***0.003 ± 0.0010.002 ± 0.001
IL-80.126 ± 0.0120.112 ± 0.0220.156 ± 0.0200.067 ± 0.022***0.159 ± 0.0400.076 ± 0.028***
TNF-β0.037 ± 0.0020.084 ± 0.022**0.003 ± 0.0020.004 ± 0.0040.038 ± 0.0040.024 ± 0.003*
MCP-1NDNDNDND0.009 ± 0.0020.002 ± 0.001*
MCP-2NDNDNDND0.001 ± 0.0010.004 ± 0.002
MIP-1α0.020 ± 0.0020.107 ± 0.018***0.006 ± 0.0020.049 ± 0.013*0.013 ± 0.0020.067 ± 0.023***
MIP-1β0.102 ± 0.0070.201 ± 0.034**0.062 ± 0.0050.089 ± 0.0150.137 ± 0.0090.170 ± 0.052*
TNF0.016 ± 0.0010.078 ± 0.023***0.006 ± 0.0060.004 ± 0.0020.006 ± 0.0020.019 ± 0.004**
  • a Expression of inflammatory mRNAs from patients and control subjects in whole-blood leukocytes, granulocytes, and monocytes (normalized to B2M mRNA and in alphabetical order). P values are according to the Mann-Whitney test: *, P < 0.05; **, P < 0.01; ***, P < 0.001 (versus controls).

  • b ND, not detectable.