TABLE 5.

Correlation between monocyte and granulocyte inflammatory mRNA expression and mortality in patients with sepsis caused by B. pseudomallei

mRNA from gene encoding indicated productExpression (mean ± SEM)a in:
LeukocytesGranulocytesMonocytes
SurvivorsNonsurvivorsSurvivorsNonsurvivorsSurvivorsNonsurvivors
IL-1β0.318 ± 0.0250.291 ± 0.0500.237 ± 0.0280.244 ± 0.0710.088 ± 0.0230.202 ± 0.073*
IL-1RA0.562 ± 0.0430.773 ± 0.1350.708 ± 0.0930.670 ± 0.1450.414 ± 0.0980.827 ± 0.287*
IL-15-R010.250 ± 0.0730.266 ± 0.029*0.097 ± 0.0220.149 ± 0.0260.118 ± 0.0120.182 ± 0.038
MIP-1α0.067 ± 0.0090.110 ± 0.0220.038 ± 0.0170.048 ± 0.0190.024 ± 0.0040.115 ± 0.059*
NF-κB10.300 ± 0.0160.378 ± 0.0460.330 ± 0.0480.379 ± 0.0680.264 ± 0.0390.434 ± 0.075*
NF-κB inhibitor alpha0.548 ± 0.0541.089 ± 0.168**0.543 ± 0.0880.676 ± 0.1560.377 ± 0.1151.134 ± 0.359**
TNF receptor superfamily 1A0.718 ± 0.0520.782 ± 0.1060.594 ± 0.0920.600 ± 0.2950.346 ± 0.0760.553 ± 0.127*
SERPINB90.247 ± 0.0290.402 ± 0.0970.155 ± 0.0470.315 ± 0.069*0.351 ± 0.0620.552 ± 0.150
  • a Expression of inflammatory mRNAs from survivors (n = 20) and nonsurvivors (n = 14) in whole-blood leukocytes, granulocytes, and monocytes (normalized to B2M mRNA and in alphabetical order). Only the inflammatory mRNAs with a significant relation to outcome are shown. P values are according to the Mann-Whitney test: *, P < 0.05; **, P < 0.01 (versus survivors).