TABLE 3.

Antibodies against rCD recognize multiple M. catarrhalis isolates regardless of whether the isolates are reactive toward MAb 3.9Ha

M. catarrhalis isolateReactivity toward MAbb:Whole-cell titer of wk 6 anti-rCD serumc
7D63.9H
125:114++148,824
115:142++39,453
205:211++35,006
110:070++33,134
306:155++22,930
204:206++97,119
B46++31,062
422:318++25,710
312:171++160,972
J261++100,826
113:136++25,663
205:333++78,120
046E++52,217
218:038+57,518
417:082+16,160
4608+103,523
5193+110,915
15P9B1+106,339
PBCC25081,227
  • a Mice were immunized with 5 μg of rCD with MPL plus alum as adjuvant.

  • b Reactivity of cell lysates in Western blot assay.

  • c Preimmune serum had a whole-cell titer of <50.