TABLE 4.

Expression of signal transduction molecules and others

mRNA from gene encoding indicated productExpression (mean ± SEM)a in:
LeukocytesGranulocytesMonocytes
ControlsPatientsControlsPatientsControlsPatients
BMI-1 oncogene homolog0.106 ± 0.0050.130 ± 0.0230.030 ± 0.0050.036 ± 0.0090.149 ± 0.0100.115 ± 0.009
Cyclin-dependent kinase inhibitor 1A0.048 ± 0.0020.160 ± 0.024***0.008 ± 0.0030.046 ± 0.009**0.142 ± 0.0120.295 ± 0.037***
GSTP10.029 ± 0.0020.086 ± 0.022***0.004 ± 0.0020.004 ± 0.0020.046 ± 0.0040.044 ± 0.005
v-Myc oncongene homolog0.174 ± 0.0090.212 ± 0.0410.048 ± 0.0070.076 ± 0.0230.297 ± 0.0240.269 ± 0.027
NF-κB10.183 ± 0.0100.424 ± 0.064***0.130 ± 0.0130.323 ± 0.036***0.231 ± 0.0110.320 ± 0.037
NF-κB20.025 ± 0.0020.100 ± 0.026***0.004 ± 0.0020.016 ± 0.0050.004 ± 0.0010.015 ± 0.005
NF-κB inhibitor alpha0.212 ± 0.0120.835 ± 0.086***0.151 ± 0.0150.570 ± 0.076***0.190 ± 0.0090.662 ± 0.155***
Polyadenylate-specific RNase0.160 ± 0.0060.214 ± 0.0340.087 ± 0.00060.109 ± 0.0140.176 ± 0.0120.153 ± 0.013
Phosphodiesterase 4B, cyclic AMP specific0.266 ± 0.0120.387 ± 0.0420.257 ± 0.0220.347 ± 0.0320.256 ± 0.0140.251 ± 0.041
PDGFB0.024 ± 0.0010.117 ± 0.048***NDbND0.024 ± 0.0030.017 ± 0.003
Protein-tyrosine phosphatase, type 4A, 20.709 ± 0.0231.0230 ± 0.053***0.423 ± 0.0330.972 ± 0.111***0.929 ± 0.0511.218 ± 0.095*
Protein-tyrosine phosphatase, nonreceptor type, 10.040 ± 0.0020.132 ± 0.023***0.022 ± 0.0040.054 ± 0.009*0.055 ± 0.0040.094 ± 0.012**
TF0.010 ± 0.0010.0870 ± 0.047***NDNDNDND
SERPINB90.201 ± 0.0100.451 ± 0.069***0.080 ± 0.0080.205 ± 0.0036*0.314 ± 0.0220.422 ± 0.065
Thrombospondin 10.026 ± 0.0020.096 ± 0.023***0.004 ± 0.0020.016 ± 0.0070.052 ± 0.0060.156 ± 0.025***
  • a Expression of inflammatory mRNAs from patients and control subjects in whole-blood leukocytes, granulocytes, and monocytes (normalized to B2M mRNA and in alphabetical order). P values are according to the Mann-Whitney test: *, P < 0.05; **, P < 0.01; ***, P < 0.001 (versus controls).

  • b ND, not detectable.