Table 2.

Survival of group C meningococcal strains grown with and without exogenous CMP-NANA in the presence of neutrophils without complement and antibodya

StrainBinding of MAb 1B2 (OD405b) to strains grown:% Survival of strains grown:P
Without CMP-NANAWith CMP-NANAWithout CMP-NANAWith CMP-NANA
8026 0.87 ± 0.140.42 ± 0.1130 ± 765 ± 160.02
150290.78 ± 0.120.38 ± 0.0732 ± 1654 ± 140.008
150310.67 ± 0.070.22 ± 0.0324 ± 634 ± 100.07
150210.60 ± 0.170.24 ± 0.0230 ± 1437 ± 3NS
  • a Values are means (± standard deviations) for three experiments. The two-tailed paired t test was used to compare results. Decreased binding of MAb 1B2 indicates that more sialic acid bound to LNnT. NS, not significant.

  • b As measured by ELISA.