Table 2.

Histopathology of lung tissue after intranasal challenge with 107 CFU of S. pneumoniae

Time (h)% of lung involvedScoreOverall scorea
Inflammatory cellsHemorrhageInterstitial edemaTissue injuryRegeneration
00000000
4151000015
12301000030
246011111300
487521222675
7210022221900
96100222221,000
  • a Calculated as percentage of lung involvement × scoring grid (inflammatory cells + hemorrhage + edema + tissue injury + regeneration). See Table 1 for explanations of scoring grid.