Table 2.

Clearance of Chlamydia from the female genital tract in iNOS knockout and immunocompetent control micea

No. of wk postinfectioniNOS+/+miceiNOS−/− mice
% InfectedNo. of IFU (mean)b% InfectedNo. of IFU (mean)b
1100 (12/12)c 7.6 × 104 100 (12/12)1.6 × 105
2100 (12/12)1.5 × 104 100 (12/12)7.0 × 103
391.7 (11/12)5.9 × 103 41.6 (5/12)1.3 × 101
48.3 (1/12)8.6 × 101 00
50000
  • a iNOS+/+ mice were (C57BL/6 × 129/J)F2; iNOS−/− mice were a third-generation random intercross of C57BL/6 mice homozygous for a 129/SvEv embryonic stem-derived mutant iNOS gene. Therefore, both iNOS+/+ and iNOS−/− mice are segregating for all other loci.

  • b Mean number of recoverable chlamydial IFU from the indicated number of mice at selected time points following intravaginal infection with MoPn as described in Materials and Methods.

  • c Values in parentheses indicate the number of mice infected relative to the total number of mice.