Table 1.

Splenic immune response parameters of iNOS-deficient and control micea

Mouse typeCD3+ cells (% of total)bIFN-γ production (pg/ml)cMac-1+ cells (% of total)dMHC class II+ cells (% of total)e
iNOS−/− 34.67 (1.2)888.33 (55.8)5.33 (0.3)53.75 (1.8)
iNOS+/+ 38.0 (0.9)885.0 (48.3)5.33 (0.3)51.50 (2.1)
  • a Total splenic cells from either naive iNOS−/− or iNOS+/+ mice were stained with fluorescent-labeled monoclonal antibodies against the leukocyte antigen indicated. Nylon wool-purified T cells (97.6% CD3+) were stimulated with 5 μg of ConA per ml for 3 days, and the supernatants were assayed for IFN-γ as described in Materials and Methods. Results represent data from at least three independent experiments and are expressed as means with standard errors of the means shown in parentheses.

  • b Results are significantly different atP = 0.059.

  • c Results are significantly different atP = 0.965.

  • d Results are significantly different atP = 1.0.

  • e Results are significantly different atP = 0.664.