Table 1.

Infection of different mouse strains withH. pylori SS1

Mouse strainNo. of mice positive/totalaLog CFU/g of tissueb,cConcn in serum (μg)c,d
UreaseCultureIgG1IgG2a
Swiss8/1010/105.69 ± 0.50*0.28 ± 0.36†0.19 ± 0.15‡
BALB/c2/1010/105.28 ± 0.820.60 ± 0.381.19 ± 0.27
C57BL/67/1010/105.64 ± 0.59*0.29 ± 0.22*0.05 ± 0.04‡
  • a Mice each received 1.2 × 105 CFU of H. pylori SS1. The presence ofH. pylori infection in gastric biopsies was assessed at 1 month p.i. by urease activity and culture.

  • b The numbers of H. pylori CFU recovered following homogenization of gastric biopsy samples. The results are presented as geometric means for 10 mice per group ± SD (for duplicate determinations).

  • c ∗, P ≥ 0.05 versus BALB/c mice; † and ‡, P = 0.014 and 0.0002, respectively, versus BALB/c mice.

  • d The quantities of anti-H. pylori IgG subclass antibodies in the sera of infected mice were determined by ELISA. Results are the means ± SD for triplicate determinations per mouse (n = 10/group).