Table 1.

Serotype specificity and molecular characteristics of MAbs reactive with C. neoformans GXM

MAb groupaMAbIsotypeSerotype specificityMolecular structureReferences
ABCDVH familyJHD sizeVLJL
II439IgG1++++718327κ5.11 2,5, 15, 50
471IgG1++++718327κ5.11 2,5, 50
3C2IgG1++++718327κ5.11 2,5, 50
III339IgG1+++1046κ215 2,5, 50
1255IgG1+++1046κ215 2,5, 15, 50
IV302IgG1++VGam26κ4/51 2,5, 15, 50
386IgM+±±+VGam34κ4/51 2,5, 50
  • a Based on differences in antibody variable region usage, which determines antibody molecular structure (5).