TABLE 2.

Replication of luminescent M. paratuberculosis S-23 in male and female BALB.B10 and (B6 × D2)F1 mice

OrganTime after infectionbColonizationa
BALB.B10(B6 × D2)F1
MFMF
Spleend15.09 ± 0.13 (5)4.84 ± 0.18 (4)5.25 ± 0.14 (3)5.44 ± 0.08 (5)
w2ND4.65 ± 0.38 (4)4.32 ± 0.09 (3)4.27 ± 0.09 (3)
w45.01 ± 0.13 (5)5.03 ± 0.12 (5)3.83 ± 0.07 (5)3.81 ± 0.07 (5)
w84.94 ± 0.23 (6)5.08 ± 0.30 (4)3.29 ± 0.06 (5)3.46 ± 0.17 (5)
w124.81 ± 0.20 (4)4.80 ± 0.38 (6)3.64 ± 0.14 (6)3.54 ± 0.11 (7)
Liverd15.43 ± 0.14 (5)5.51 ± 0.21 (4)5.57 ± 0.26 (3)5.84 ± 0.08 (5)
w2ND5.09 ± 0.12 (4)3.98 ± 0.13 (3)4.03 ± 0.10 (3)
w45.95 ± 0.04 (5)6.09 ± 0.05 (5)4.23 ± 0.08 (5)4.24 ± 0.24 (5)
w85.55 ± 0.22 (6)5.61 ± 0.45 (4)3.40 ± 0.11 (5)3.39 ± 0.11 (5)
w125.34 ± 0.55 (4)4.82 ± 0.58 (6)3.26 ± 0.07 (6)3.20 ± 0.03 (6)
Lungsd14.80 ± 0.17 (5)4.99 ± 0.40 (4)4.48 ± 0.18 (3)4.67 ± 0.20 (5)
w2ND3.81 ± 0.10 (4)3.27 ± 0.03 (3)3.57 ± 0.16 (3)
w43.26 ± 0.39 (5)3.07 ± 0.15 (5)2.92 ± 0.04 (5)2.93 ± 0.09 (5)
w83.82 ± 0.75 (6)4.05 ± 0.81 (4)3.01 ± 0.10 (5)2.95 ± 0.14 (5)
w123.52 ± 0.69 (4)3.55 ± 0.73 (6)2.92 ± 0.07 (6)2.99 ± 0.20 (6)
  • a Colonization levels of M. paratuberculosis S-23 in male (M) and female (F) BALB.B10 and (B6 × D2)F1 mice in spleen, liver, and lungs, as quantified on day 1 and 2, 4, 8 and 12 weeks after intravenous infection. The data represent mean log10 RLU±standard deviation from three to six mice (numbers are given in parentheses). ND, not determined.

  • b d, day; w, week.