TABLE 3.

Persistence of recombinant S. enterica serovar Choleraesuis vaccine strain C501(pYA-F1P2) in deep organs of BALB/c micea

RouteLog10 CFU recovered from:
Lungs on day:Spleen on day:Peyer's patches on day:
281428142814
s.c.2.7*3.41.42.6*3.2*1.72.63.32.5
Oral1.6NDND1.9<1bND2.83.52.3
  • a Mice were inoculated orally or s.c. with a single dose of 2.1×1010 or 2.1×108 CFU C501(pYA-F1P2) organisms. Data are averages of values for four mice, and ND represents no detectable organisms. *, P < 0.01 by Student's t test between the s.c. and orally inoculated groups.

  • b One mouse had low counts of vaccine organisms, and the other three mice had cleared all organisms.