TABLE 2.

High levels of proinflammatory cytokines in the lungs correlate directly with the bacterial concentrationa

MouseBacterial load in wild type (log10 CFU/g of tissue)Bacterial concn (pg/sample)b
TNF-αMCP-1IL-6
15.50430.2163.4231.1
24.59128.887.825.3
39.782,961.31,666.85,000.0
49.722,576.41,268.15,000.0
510.625,000.03,093.25,000.0
Mean ± SD8.04 ± 2.782,219.3 ± 1,998.81,255.9 ± 1,235.23,051.3 ± 2,669.4
  • a Mice were infected with 104 CFU of wild-type bacteria, and lungs were harvested at 72 h. Data are taken from the experiment described in Fig. 2.

  • b Correlations: TNF-α, r2 = 0.8791 and P = 0.0185; MCP-1, r2 = 0.8008 and P = 0.0403; IL-6, r2 = 0.9757 and P = 0.0016.