Table 5.

Degradation of cytokines by bacterial proteases

OrganismCytokine(s) degradedEnzyme(s) responsibleReference(s)
Pseudomonas aeruginosa IL-2, TNF-αAlkaline protease, elastase 42, 50
IFN-γAlkaline protease 30
Legionella pneumophila IL-2Zn-metalloproteinase 41
Porphyromonas gingivalis IL-1β, IL-6, IL-1raGingipain 16, 17