Table 4.

Suppression of cytokine synthesis

OrganismProcess inhibitedaActive componentReference
Actinomyces actinomycetemcomitans Release of IL-2, IL-4, IL-5, and IFN-γ from ConA-stimulated murine CD4+ cells14-kDa protein 34
Escherichia coli Expression of mRNA for IL-2, IL-4, IL-5, and IFN-γ in PMA-stimulated PBMCs8-kDa protein 33
Yersinia enterocolitica TNF-α release from LPS-stimulated murine macrophagesYopB 3
Brucella suis TNF-α release from E. coli-infected macrophages45- to 50-kDa protein 6
Vibrio cholerae TNF-α release from rat peritoneal mast cellsCholera toxin 35
Bacillus anthracis TNF-α secretion by LPS-stimulated human monocytesAnthrax edema toxin 29
Pseudomonas aeruginosa Synthesis of IL-1α, IL-1β, TNF-α, and IFN-γ by PHA-stimulated human monocytesADP-ribosylating toxin 48
TNF-α and IL-12 release from LPS-stimulated human monocytes3-Oxododecanoyl-l-homoserine lactone 58
Salmonella typhimurium Synthesis of IL-2 by murine T lymphocytesProtein 38
  • a ConA, concanavalin A; PBMCs, peripheral blood mononuclear cells; PHA, phytohemagglutinin.