Table 1.

Geometric means of Pn6B antibody levels in sera of infants and adults injected with Pn6B-TT

Ab (unit)Result for groupa(Pb)
Adults (HA)Infant group A (age [mo])Infant group B (age [mo])
PrePost71924101924
Total Ab (ng of Ab N/ml)339.8 (<0.001)1,372.544.3 (<0.001)723.0 (0.054)444.36 (<0.05)211.4 (<0.001)1,068.0 (0.425)723.17 (0.267)
IgM (μg/ml)3.20 (<0.05)4.891.07 (<0.001)2.47 (<0.05)3.11 (<0.05)1.87 (<0.01)3.29 (0.123)3.41 (0.083)
IgA (μg/ml)0.42 (<0.001)0.960.04 (<0.001)0.09 (<0.001)0.06 (<0.001)0.06 (<0.001)0.05 (<0.001)0.07 (<0.001)
IgG (μg/ml)2.45 (<0.001)7.320.62 (<0.001)2.46 (<0.05)1.59 (<0.001)1.22 (<0.001)4.80 (0.510)2.22 (<0.05)
IgG1 (AU/ml)2.24 (<0.001)15.324.93 (0.054)54.48 (0.050)15.70 (0.987)17.70 (0.945)84.12 (<0.05)23.52 (0.504)
IgG2 (AU/ml)7.15 (<0.001)19.210.23 (<0.001)0.48 (<0.001)0.48 (<0.001)0.34 (<0.001)1.64 (<0.001)0.70 (<0.001)
  • a Seven months (group A) and 10 months (group B), 1 month after primary injections with Pn6B-TT. Nineteen and 24 months, 1 and 6 months after booster injections.

  • b P value for statistical comparison with adult (group HA) post-Pn6B-TT vaccination levels.