TABLE 2.

Ex vivo IFN-γ ELISPOT responses for DDM-ME TRAP and DDM-CS

Time pointbResults for group 1Results for group 2 (all peptides in vaccines [3D7 CS])
All peptides in vaccines (ME + T996 TRAP)Vaccine strain (T996 TRAP)Challenge strain (3D7 TRAP)
AMSEMGMAMSEMGMAMSEMGMAMSEMGM
D0176.710114.182312.385519.721
D+7256.117193.814235.4183815.622
D+28123.7882.06164.013248.46
DD+73211.619249.396219.637145.64
DD+282514.861510.621810.58275.723
DDM+7609174.5423428138.0294376146.82119935.854
DDMC32396.219024083.012017154.48812939.479
DDMC+712044.0479033.7377420.8396023.732
DDMC+90199.210168.18147.35144.810
  • a The geometric mean (GM), arithmetic mean (AM), and standard error of the mean are shown for each time point in group 1 (DDM-ME TRAP) for all of the peptides in the vaccine (multiple epitope string [ME] and T996 TRAP), for T996 TRAP (vaccine strain), and for the 3D7 TRAP (challenge strain) and for each time point in group 2 (DDM-CS) for the CS peptides.

  • b D0 = day 0, D+7 = first DNA vaccination plus 7 days, D+28 = first DNA vaccination plus 28 days (same as the day of the second vaccination), DD+7 = second DNA vaccination plus 7 days, DD+28 = second DNA vaccination plus 28 days (same as the day of the MVA vaccination), DDM+7 = MVA vaccination plus 7 days, DDMC = day of challenge (same as the day of MVA vaccination plus 14 days), DDMC+7 = day of challenge plus 7 days, and DDMC+90 = day of challenge plus 90 days.