Table 3.

Comparison of circulating ASC responses with immune responses in intestinal lavage after two oral immunizations with ETEC vaccinea

ParameterValue (%) for vaccine antigen
CFA/ICS1/3CS2CS4CTB
Sensitivity85818380100
Positive predictive value8972718096
  • ↵a Samples collected 7 days (blood) and 9 days (lavage) after the second dose from 22 or 23 vaccinees were assayed for specific IgA antibodies per total IgA responses in lavage and for blood IgA ASC responses against the respective antigens. The percentage of volunteers mounting both ASC and lavage responses in relation to those responding in lavage (sensitivity) and to those mounting ASC responses (positive predictive value) is given for each antigen.